Dextran Sulfate Sodium Salt (DSS) MW: 36000~50000

Mfr.No.

60316ES80, 60316ES76, 60316ES25, 60316ES60

Description

Dextran sulfate sodium salt (DSS) is a polyanionic derivative of dextran produced by the esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. DSS has several characteristics: 1) polyanionic complex, soluble in water, forming a colorless aqueous solution; 2) high purity and good stability; 3) can be degraded naturally. Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including UC and Crohn disease (CD). In 1985, after the hamster ulcerative colitis model was first prepared by using DSS, a large number of studies have proved that the DSS colitis model is similar to human ulcerative colitis. The histological features, clinical manifestations, disease site, and cytokine proliferation of the DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, the expenditure is very cheap, the repeatability is good, and it is easy to master and popularize. The DSS concentration and dosing time can be adjusted according to the experimental purpose to establish acute, chronic, and acute-chronic alteation models

Alternative Names

Dextran Sulfate Sodium Salt, DSS; Dextran Sodium Sulfate

Appearance

White or off-white powder

Features

The protocols are easy to be implemented.
The DSS UC model closely resembles human UC symptoms with high repeatability.
Various characteristic symptoms can be induced by controlling the administrated DSS dose, which was unique for the DSS UC model.
The DSS UC model can be generated with a variety of widely used model animals, such as mice, rats, zebrafish, pigs, fruit flies, etc.
The IBD-induced colitis-associated cancer (CAC) model can be created with the combined use of azoxymethane (AOM).

Kit Components

Components No.	Name	60316ES25	60316ES60	60316ES76	60316ES80
60316	Dextran Sulfate Sodium Salt (DSS) MW:36000~50000	25 g	100 g	500 g	1 kg

Molecular Formula

(C₆H₇Na₃O₁₄S₃)n

Cas Number

9011-18-1

Solubility

Soluble in water, slightly soluble in ethanol.

Shipping Temperature	Room temperature
Storage	Stored at room temperature, valid for 2 years.

Product Manual	Safety Data Sheet Manual

Reference	[1] Li Zhao, Fei Wang,Zhengwei Cai,et al.Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis[J].chemical engineering joual.424(2021)130464.IF=16.744 [2] Lingjun Tong, Haining Hao, Zhe Zhang,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics.2021; 11(17): 8570-8586 IF=11.556 [3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245 [4] Jingjing Gan, Yuxiao Liu, Lingyu Sun,et al.Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment[J].Applied Materials Today.2021 Dec;25:101231 IF=10.041 [5] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423 [6] Hao H, Zhang X, Tong L, Liu Q,et al.Lactobacillus plantarumEffect of Extracellular Vesicles Derived From Q7 on Gut Microbiota and Ulcerative Colitis in Mice[J].Frontiers in Immunology.2021.777147 .IF=7.561 [7] Yaohua Fan,Yanqun Fan,Kunfeng Liu,et al.Edible Bird’s Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance[J].Frontiers in Pharmacology.2021.632602.IF=7.561 [8] Jia-Rong Huang, Sheng-Te Wang, Meng-Ning Wei,et al.Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer[J].Frontiers in Pharmacology.2020.586885. IF=7.561 [9] Mengmeng Xu, Ying Kong, Nannan Chen,et al.Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis[J].Frontiers in Immunology.2022; 13: 855645. IF=7.561 [10] Gao X, Fan W, Tan L, et al. Soy isoflavones ameliorate experimental colitis by targeting ERα/NLRP3 inflammasome pathways[J]. The Joual of Nutritional Biochemistry, 2020, 83.IF=6.048

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Combination SKU	Supplier No.	Size	Your price
BHB20800004-1	60316ES80	1kg	$5105	Add to Cart
BHB20800004-2	60316ES76	500g	$2795	Add to Cart
BHB20800004-3	60316ES25	25g	$215	Add to Cart
BHB20800004-4	60316ES60	100g	$645	Add to Cart

Dextran Sulfate Sodium Salt (DSS) MW: 36000~50000

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