DBeQ

Mfr.No.	SIH-334
Alternative Names	N,N'-Dibenzyl-2,4-quinazolinediamine, JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine, N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Appearance	Yellow Powder
Function	p97 inhibitor
Inchi	InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
Inchikey	QAIMUUJJAJBPCL-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H20N4
Pubchem Cid	676352
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Toxic Material Causing other toxic effects- moderate eye irritant. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed Precautionary Statements: P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Smiles	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	340.4
Scientific Background	A potent, selective and reversible inhibitor of the AAA-ATP p97 (ATPase associated with diverse cellular activities). Ki=3.2 M. It blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
Solubility	Soluble in 25 mg/ml DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Chou T.F., et al. 2011 PNAS 108:4834.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900123-1	SIH-334-5MG	5 mg	$75		Add to Cart
BHB11900123-2	SIH-334-25MG	25 mg	$323		Add to Cart