CU-32

Mfr.No.	T38328
Description	CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 uM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 uM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 uM.
Molecular Formula	C11H10IN5O2
Signaling Pathways	Others
Smiles	N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2
Cas Number	2400954-16-5
Molecular Weight	371.13
Target	Others

Have you used this product?

SKU	Supplier No.	Size	Your price
BHB20427282	T38328	1 mg	$198	Add to Cart
BHB20427282	T38328	5 mg	$695	Add to Cart
BHB20427282	T38328	10 mg	$1180	Add to Cart