Chloroquine diphosphate

Mfr.No.	SIH-405
Alternative Names	N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Appearance	Beige Solid
Function	Autophagy inhibitor
Inchi	InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;21-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2(H3,1,2,3,4)
Inchikey	QKICWELGRMTQCR-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C18H26ClN3·2H3PO4
Pubchem Cid	64927
Sd File	C18H32ClN3O8P2 APtclcactv04251417342D 0 0.00000 0.00000 64 63 0 0 0 0 0 0 0 0999 V2000 11.4464 6.5023 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4464 8.5716 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8204 7.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3524 7.0161 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8204 8.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8204 4.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9544 3.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9544 2.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0883 1.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2223 2.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9544 5.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2223 0.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3563 2.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2233 5.2269 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6864 6.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3524 8.0578 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8204 5.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2165 8.5611 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.0883 2.0369 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6864 5.5369 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8059 6.6585 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.2785 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2130 7.8715 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9030 5.6025 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.2690 6.9685 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.5369 5.9685 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9030 7.3345 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5524 7.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5524 8.0369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6864 8.5369 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.5179 11.2050 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4209 12.2610 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6150 11.8810 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8279 13.4740 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8840 12.5710 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.1519 11.5710 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5179 12.9370 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4030 6.4685 0.0000 P 0 0 0 0 0 0 0 0 0 0 0 0 9.0179 12.0710 0.0000 P 0 0 0 0 0 0 0 0 0 0 0 0 11.4392 5.8823 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4392 9.1916 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2835 6.7269 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8882 6.7041 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2835 8.3469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8204 5.6569 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0324 3.4543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4310 4.1446 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2644 6.0739 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4174 5.8469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6444 5.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7423 4.1195 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3438 3.4293 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1664 1.9543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5649 2.6446 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3004 0.4543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6989 1.1446 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6208 3.0119 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8238 3.0119 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9123 1.0739 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6854 0.2269 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5323 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0463 2.5739 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8194 1.7269 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6663 1.5000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 28 29 2 0 0 0 0 15 28 1 0 0 0 0 1 28 1 0 0 0 0 29 30 1 0 0 0 0 2 29 1 0 0 0 0 3 15 2 0 0 0 0 15 20 1 0 0 0 0 1 4 2 0 0 0 0 5 30 2 0 0 0 0 2 16 2 0 0 0 0 17 20 1 0 0 0 0 16 18 1 0 0 0 0 6 17 1 0 0 0 0 11 17 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 8 19 1 0 0 0 0 9 19 1 0 0 0 0 10 19 1 0 0 0 0 9 12 1 0 0 0 0 10 13 1 0 0 0 0 25 38 1 0 0 0 0 26 38 1 0 0 0 0 27 38 1 0 0 0 0 24 38 2 0 0 0 0 35 39 1 0 0 0 0 36 39 1 0 0 0 0 37 39 1 0 0 0 0 31 39 2 0 0 0 0 3 5 1 0 0 0 0 4 16 1 0 0 0 0 1 40 1 0 0 0 0 2 41 1 0 0 0 0 3 42 1 0 0 0 0 14 20 1 0 0 0 0 4 43 1 0 0 0 0 5 44 1 0 0 0 0 17 45 1 0 0 0 0 6 46 1 0 0 0 0 6 47 1 0 0 0 0 11 48 1 0 0 0 0 11 49 1 0 0 0 0 11 50 1 0 0 0 0 7 51 1 0 0 0 0 7 52 1 0 0 0 0 8 53 1 0 0 0 0 8 54 1 0 0 0 0 9 55 1 0 0 0 0 9 56 1 0 0 0 0 10 57 1 0 0 0 0 10 58 1 0 0 0 0 12 59 1 0 0 0 0 12 60 1 0 0 0 0 12 61 1 0 0 0 0 13 62 1 0 0 0 0 13 63 1 0 0 0 0 13 64 1 0 0 0 0 21 25 1 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 32 35 1 0 0 0 0 33 36 1 0 0 0 0 34 37 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1=CC(=CC2=C1C(=CC=N2)NC(CCCN(CC)CC)C)Cl.O=[P](O)(O)O.O=[P](O)(O)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	50-63-5
Molecular Weight	515.86
Scientific Background	Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.
Solubility	Soluble to 100 mM in water.
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	1
Purity	≥98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14. 2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900193-1	SIH-405-1G	1 g	$33		Add to Cart

Chloroquine diphosphate

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