BRL-50481

Mfr.No.	SIH-374
Alternative Names	N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Appearance	Cream solid
Function	PDE7 inhibitor
Inchi	InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
Inchikey	IFIUFCJFLGCQPH-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C9H12N2O4S
Pubchem Cid	2921148
Research Area	Neuroscience
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	433695-36-4
Molecular Weight	244.26
Scientific Background	BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
Solubility	May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89. 2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900162-1	SIH-374-10MG	10 mg	$80		Add to Cart
BHB11900162-2	SIH-374-50MG	50 mg	$311		Add to Cart