Brefeldin A

Mfr.No.	SIH-225
Alternative Names	Cyanaein
Appearance	White Crystalline Solid
Function	GEF inhibitor
Inchi	InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,
Inchikey	KQNZDYYTLMIZCT-PNFJWZTBSA-N
Mode Of Action	Inhibitor
Molecular Formula	C16H24O4
Pubchem Cid	5287620
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310
Smiles	C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	20350-15-6
Molecular Weight	280.36
Scientific Background	Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
Solubility	Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900049-1	SIH-225-5MG	5 mg	$56		Add to Cart
BHB11900049-2	SIH-225-25MG	25 mg	$224		Add to Cart