Bractoppin

Mfr.No.	T8873
Description	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 uM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
Molecular Formula	C25H23FN4O
Signaling Pathways	Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others
Smiles	C(=O)(C=1C=C2C(N=C(N2)C3=CC=CC=C3)=CC1)N4CCN(CC5=C(F)C=CC=C5)CC4
Cas Number	2290527-07-8
Molecular Weight	414.47
Target	Others, DNA/RNA Synthesis

Have you used this product?

SKU	Supplier No.	Size	Your price
BHB20446889	T8873	1 mL	$117	Add to Cart
BHB20446889	T8873	1 mg	$45	Add to Cart
BHB20446889	T8873	5 mg	$106	Add to Cart
BHB20446889	T8873	10 mg	$169	Add to Cart
BHB20446889	T8873	25 mg	$343	Add to Cart
BHB20446889	T8873	50 mg	$516	Add to Cart
BHB20446889	T8873	100 mg	$775	Add to Cart
BHB20446889	T8873	500 mg	$1560	Add to Cart