Astemizole

Mfr.No.	SIH-302
Alternative Names	1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
Appearance	White solid
Function	Herg channel blocker
Inchi	InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-2
Inchikey	GXDALQBWZGODGZ-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C28H31FN4O
Pubchem Cid	2247
Research Area	Neuroscience ; Ion Channels
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62 - Possible risk of impaired fertility Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
Smiles	COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	68844-77-9
Molecular Weight	458.57
Scientific Background	Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
Solubility	Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300. 2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900091-1	SIH-302-10MG	10 mg	$68		Add to Cart
BHB11900091-2	SIH-302-50MG	50 mg	$265		Add to Cart

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