AG 879

Mfr.No.	SIH-429
Alternative Names	Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Appearance	Yellow solid
Function	NGFR kinase inhibitor
Inchi	InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
Inchikey	LCUMYVYIHXYBIA-FOWTUZBSSA-N
Mode Of Action	Inhibitor
Molecular Formula	C18H24N2OS
Pubchem Cid	5487525
Sd File	C18H24N2OS APtclcactv07301412482D 0 0.00000 0.00000 46 46 0 0 0 0 0 0 0 0999 V2000 4.5981 3.4050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5981 2.4050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5981 2.4050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -1.0950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3660 -1.4610 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3660 0.2710 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 -3.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6592 -3.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 1.4050 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -1.5950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -2.0950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 1.4050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -0.0950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.9050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -0.0950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -0.5950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -3.0950 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.9050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -0.5950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 2.4050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.5950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -2.0950 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -2.5950 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 -1.5950 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 5.2181 3.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 4.0250 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9781 3.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5981 1.7850 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2181 2.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5981 3.0250 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5981 3.0250 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9781 2.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5981 1.7850 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6900 -0.5581 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -1.4050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3100 -1.6319 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8291 -1.7710 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6760 -1.9980 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9030 -1.1510 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9030 0.5810 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0560 0.8080 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8291 -0.0390 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 1.2150 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.2150 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -0.2850 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5991 -1.9050 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11 24 1 0 0 0 0 24 46 1 0 0 0 0 9 14 2 0 0 0 0 11 17 1 0 0 0 0 7 17 1 0 0 0 0 8 17 1 0 0 0 0 22 23 3 0 0 0 0 12 20 1 0 0 0 0 1 20 1 0 0 0 0 2 20 1 0 0 0 0 3 20 1 0 0 0 0 13 21 1 0 0 0 0 4 21 1 0 0 0 0 5 21 1 0 0 0 0 6 21 1 0 0 0 0 12 14 1 0 0 0 0 12 18 2 0 0 0 0 13 14 1 0 0 0 0 13 19 2 0 0 0 0 1 25 1 0 0 0 0 1 26 1 0 0 0 0 1 27 1 0 0 0 0 2 28 1 0 0 0 0 2 29 1 0 0 0 0 2 30 1 0 0 0 0 3 31 1 0 0 0 0 3 32 1 0 0 0 0 3 33 1 0 0 0 0 4 34 1 0 0 0 0 4 35 1 0 0 0 0 4 36 1 0 0 0 0 5 37 1 0 0 0 0 5 38 1 0 0 0 0 5 39 1 0 0 0 0 6 40 1 0 0 0 0 6 41 1 0 0 0 0 6 42 1 0 0 0 0 15 18 1 0 0 0 0 18 43 1 0 0 0 0 15 19 1 0 0 0 0 19 44 1 0 0 0 0 15 16 2 0 0 0 0 10 16 1 0 0 0 0 16 45 1 0 0 0 0 10 11 2 0 0 0 0 10 22 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	CC(C1=CC(C=C(C(C)(C)C)C1=O)=CC(=C(S)N)C#N)(C)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	148741-30-4
Molecular Weight	316.5
Scientific Background	A879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2.
Solubility	Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥99% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900215-1	SIH-429-5MG	5 mg	$88		Add to Cart
BHB11900215-2	SIH-429-25MG	25 mg	$365		Add to Cart

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