AG-012986 HCl

Mfr.No.	T69197
Description	AG-012986 HCl is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 HCl showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 HCl was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 HCl also showed dose-dependent retinoblastoma Ser(795) hypophosphorylation, cell cycle arrest, decreased Ki-67 tumor staining, and apoptosis in conjunction with antitumor activity.
Molecular Formula	C22H25Cl2F2N5O2S
Signaling Pathways	Others
Cas Number	486414-32-8
Molecular Weight	532.43
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20436431	T69197	25 mg	$1520	Add to Cart
BHB20436431	T69197	50 mg	$1980	Add to Cart
BHB20436431	T69197	100 mg	$2500	Add to Cart