AAPK-25

Mfr.No.	T10215
Description	AAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis. AAPK-25 targets Aurora A, Aurora B, and Aurora C with Kd values ranging from 23-289 nM, and PLK1, PLK2, and PLK3 with Kd values ranging from 55-456 nM. AAPK-25 has antitumor activity.
Molecular Formula	C21H13Cl2N3O2S
Signaling Pathways	Apoptosis, Chromatin/Epigenetic, Cell Cycle/Checkpoint
Smiles	N(C(=O)C1=CC(Cl)=C(Cl)C=C1)C2=CC3=C(C=C(C(NC4=NC=CS4)=O)C=C3)C=C2
Cas Number	2247919-28-2
Molecular Weight	442.32
Target	Apoptosis, PLK, Aurora Kinase

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SKU	Supplier No.	Size	Your price
BHB20400944	T10215	1 mL	$297	Add to Cart
BHB20400944	T10215	1 mg	$97	Add to Cart
BHB20400944	T10215	5 mg	$261	Add to Cart
BHB20400944	T10215	10 mg	$387	Add to Cart
BHB20400944	T10215	25 mg	$649	Add to Cart
BHB20400944	T10215	50 mg	$923	Add to Cart
BHB20400944	T10215	100 mg	$1260	Add to Cart
BHB20400944	T10215	500 mg	$2520	Add to Cart