5-Azacytidine

Mfr.No.	SIH-345
Alternative Names	4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U-18496; NSC-102816; 5-AzaC
Appearance	White Solid
Function	DNA hypomethylation agent
Inchi	InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
Inchikey	NMUSYJAQQFHJEW-KVTDHHQDSA-N
Mode Of Action	Inhibitor
Molecular Formula	C8H12N4O5
Pubchem Cid	9444
Research Area	Cell Signaling ; Epigenetics and Nuclear Signaling ; Cancer
Safety Phrases	Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302- Harmful if swallowed H350 – May cause cancer Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/attention
Smiles	C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	320-67-2
Molecular Weight	244.2
Scientific Background	DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Solubility	Soluble in 25 mg/ml DMSO or 12 mg/ml Water
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.25
Purity	>98% (TLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900133-1	SIH-345-50MG	50 mg	$41		Add to Cart
BHB11900133-2	SIH-345-250MG	250 mg	$110		Add to Cart

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