17-AAG

Mfr.No.	SIH-100
Alternative Names	17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-AAG, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin
Appearance	Red to dark red powder
Function	Hsp90 inhibitor
Inchi	InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30
Inchikey	AYUNIORJHRXIBJ-TXHRRWQRSA-N
Mode Of Action	Inhibitor
Molecular Formula	C31H43N3O8
Pubchem Cid	6505803
Sd File	C31H43N3O8 APtclcactv04171519182D 0 0.00000 0.00000 85 86 0 0 1 0 0 0 0 0999 V2000 9.1861 -0.6368 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 10.0521 -2.1368 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 8.1861 -0.6368 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 7.4790 -1.3439 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.9790 -0.4779 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.9790 0.5221 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 13.5162 -0.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0521 -3.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8617 -2.2678 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6049 0.3567 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7451 0.1649 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1130 2.0221 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2858 3.0566 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1809 0.7790 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6502 -1.2568 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3682 1.9559 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -1.4728 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7593 -2.2322 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0521 -1.1368 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.6502 1.3632 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2985 0.9195 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.0472 0.0397 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8034 0.2871 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.3060 -0.9262 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6087 0.2695 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.2719 -1.1850 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.1130 1.0221 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.3823 -0.6368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1861 -1.6368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9182 -1.6368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6502 -0.6368 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.2483 -0.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5989 -1.6333 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9790 -0.4779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7842 -0.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0521 -0.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7842 0.8632 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1770 1.3973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6770 2.2633 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4790 -1.3439 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9182 1.3632 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8450 1.0221 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8450 2.0221 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7111 2.5221 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9182 -0.6368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0521 0.8632 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1861 1.3632 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.7914 -0.7710 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5755 -1.5291 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9741 -2.2194 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5891 -2.4468 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5780 -0.5159 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0871 -1.4649 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1302 -2.2194 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5288 -1.5291 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4321 -3.1368 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0521 -3.7568 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6721 -3.1368 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1690 -1.8808 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2889 -2.5051 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0990 -2.8406 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4345 -2.0305 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4062 -0.2406 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6590 -0.2610 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2226 0.4107 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5509 0.9743 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9790 1.1421 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1436 -0.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2200 0.5634 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3465 0.6398 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9182 1.9832 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4556 0.9144 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9148 0.3381 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1177 0.3381 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3081 2.3321 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7330 2.0221 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1130 2.6421 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4930 2.0221 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6301 3.1368 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3823 -1.2568 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7776 2.6792 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6632 3.5485 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7939 3.4341 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7852 -0.4468 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2483 0.4832 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 25 1 6 0 0 0 10 25 1 0 0 0 0 3 23 1 6 0 0 0 14 23 1 0 0 0 0 5 26 1 1 0 0 0 24 26 1 0 0 0 0 6 27 1 6 0 0 0 12 27 1 0 0 0 0 19 36 2 0 0 0 0 20 37 2 0 0 0 0 21 38 2 0 0 0 0 22 24 2 0 0 0 0 31 35 1 0 0 0 0 7 31 1 0 0 0 0 15 31 1 0 0 0 0 46 47 1 0 0 0 0 38 47 1 0 0 0 0 16 47 1 0 0 0 0 24 33 1 0 0 0 0 17 33 1 0 0 0 0 18 33 1 0 0 0 0 1 29 1 0 0 0 0 1 3 1 0 0 0 0 1 48 1 0 0 0 0 2 29 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 2 30 1 0 0 0 0 2 8 1 1 0 0 0 2 51 1 0 0 0 0 3 4 1 0 0 0 0 3 52 1 0 0 0 0 4 40 1 0 0 0 0 4 9 1 6 0 0 0 4 53 1 0 0 0 0 30 45 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 8 56 1 0 0 0 0 8 57 1 0 0 0 0 8 58 1 0 0 0 0 34 40 2 0 0 0 0 40 59 1 0 0 0 0 35 45 2 0 0 0 0 36 45 1 0 0 0 0 9 60 1 0 0 0 0 9 61 1 0 0 0 0 9 62 1 0 0 0 0 5 34 1 0 0 0 0 11 34 1 0 0 0 0 5 6 1 0 0 0 0 5 63 1 0 0 0 0 35 37 1 0 0 0 0 36 46 1 0 0 0 0 10 64 1 0 0 0 0 10 65 1 0 0 0 0 10 66 1 0 0 0 0 6 42 1 0 0 0 0 6 67 1 0 0 0 0 11 68 1 0 0 0 0 11 69 1 0 0 0 0 11 70 1 0 0 0 0 41 46 2 0 0 0 0 37 41 1 0 0 0 0 41 71 1 0 0 0 0 42 43 2 0 0 0 0 42 72 1 0 0 0 0 7 28 1 0 0 0 0 7 73 1 0 0 0 0 7 74 1 0 0 0 0 43 44 1 0 0 0 0 43 75 1 0 0 0 0 38 39 1 0 0 0 0 12 76 1 0 0 0 0 12 77 1 0 0 0 0 12 78 1 0 0 0 0 39 44 2 0 0 0 0 13 39 1 0 0 0 0 44 79 1 0 0 0 0 28 32 2 0 0 0 0 28 80 1 0 0 0 0 13 81 1 0 0 0 0 13 82 1 0 0 0 0 13 83 1 0 0 0 0 32 84 1 0 0 0 0 32 85 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)C)C)O)OC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	75747-14-7
Molecular Weight	585.7
Scientific Background	Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Solubility	Soluble in DMSO (>50 mg/ml) or ethanol (5 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.005
Purity	>99% (HPLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Neckers L. (2002) Trends Mol Med. 84: S55-61. 2. Kamal A., et al.(2003) Nature. 425: 407. 3. Solit D.B., et al.(2003) Cancer Res. 63: 2139. 4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 65: 235. 5. Jia W., et al.(2003) Blood. 102: 1824.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900001-1	SIH-100A	1 mg	$123		Add to Cart
BHB11900001-2	SIH-100-5MG	5 mg	$404		Add to Cart

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