(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

Mfr.No.	T36610
Description	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1alpha-dependent manner through induction of IRE1alpha-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.
Molecular Formula	C15H15ClN2
Signaling Pathways	Others
Smiles	Cc1nc(C)c(C=Cc2ccccc2Cl)nc1C
Cas Number	1000672-89-8
Molecular Weight	258.75
Target	Others

Have you used this product?

SKU	Supplier No.	Size	Your price
BHB20425882	T36610	1 mg	$78	Add to Cart
BHB20425882	T36610	5 mg	$290	Add to Cart
BHB20425882	T36610	10 mg	$535	Add to Cart
BHB20425882	T36610	25 mg	$1140	Add to Cart