Fast and sensitive. Linear detection range (20 µL sample): 0.0025 to 2 U/L for 10 min reaction at 25°C. Convenient and high-throughput. Homogeneous "mix-incubate-measure" type assay. Can be readily automated on HTS liquid handling systems for processing thousands of samples per day.
Son, A., et al (2019). Ca2+ influx channel inhibitor saraf protects mice from acute pancreatitis. Gastroenterology, 157(6), 1660-1672.e2. Assay: Myeloperoxidase in mouse tissue.
Hashim, A. A., Helmy, M. M., & Mouneir, S. M. (2018). Cysteinyl leukotrienes predominantly mediate cisplatin-induced acute renal damage in male rats. Journal of Physiology and Pharmacology, 69(5), 779-787. Assay: Myeloperoxidase in rat kidney.
Helmy, M. M., Hashim, A. A., & Mouneir, S. M. (2018). Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis. Prostaglandins & other lipid mediators, 135, 1-10. Assay: Myeloperoxidase in rat tissue.
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