ELISA Kit for Rat Vascular endothelial growth factor C

Mfr.No.	E0145r
Alternative Names	Flt4 ligand ; Flt4-L ; Vascular endothelial growth factor-related protein ; VRP
Categories	Elisa
Function	Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Specificity	Natural and recombinant Rat Vascular endothelial growth factor C
Subcellular Location	Secreted
Detection Range	15.6-1000pg/mL
Entryname	VEGFC_RAT
Method Type	Sandwich
Platform	PF03128
Protein Name	Vascular endothelial growth factor C
Sensitivity	7.91pg/mL
Sequence	50: MHLLCFLSLA ; CSLLAAALIP ; GPREAPATVA ; AFESGLGFSE ; AEPDGGEVKG ; 100: FEGKDLEEQL ; RSVSSVDELM ; SVLYPDYWKM ; YKCQLRKGGW ; QQPSLNMRTG ; 150: DTVKLAAAHY ; NTEILKSIDN ; EWRKTQCMPR ; EVCIDVGKEF ; GAATNTFFKP ; 200: PCVSVYRCGG ; CCNSEGLQCM ; NTSTGYLSKT ; LFEITVPLSQ ; GPKPVTISFA ; 250: NHTSCRCMSK ; LDVYRQVHSI ; IRRSLPATLP ; QCQAANKTCP ; ANYVWNNYMC ; 300: QCLAQQDFIF ; YSNVEDDSSN ; GFHDVCGPNK ; ELDEDTCQCV ; CKGGLRPSSC ; 350: GPHKELDRDS ; CQCVCKNKLF ; LNSCGANREF ; DENTCQCVCK ; RTCPRNQPLN ; 400: PGKCACECTE ; NTQKCFLKGK ; KFHHQTCSCY ; RRPCTNRLKH ; CDPGLSFSEE ; 415: VCRCVPSYWK ; RPHLN
Sequence Length	415
String	O35757
Sub Unit	Homodimer; non-covalent and antiparallel.

Reference	1. "Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2." Kirkin V., Mazitschek R., Krishnan J., Steffen A., Waltenberger J., Pepper M.S., Giannis A., Sleeman J.P. Eur. J. Biochem.268:5530-5540(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;MUTAGENESIS OF CYS-152 strain: Sprague-Dawley. 2. "Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution." Pepper M.S., Baetens D., Mandriota S.J., Di Sanza C., Oikemus S., Lane T.F., Soriano J.V., Montesano R., Iruela-Arispe M.L. Dev. Dyn.218:507-524(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-278;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE strain: Sprague-Dawley. tissue: Lung.

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