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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Tyrosine-protein kinase SYK

SKU : BHE13806338

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1520r
Alternative Names	Spleen tyrosine kinase ; p72Syk
Categories	Elisa
Function	Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Likewise, mediates responses to ITGB2 signaling and plays an important role in the regulation of down-stream signaling cascades. Phosphorylates USP25 and regulates its intracellular levels.
Specificity	Natural and recombinant Rat Tyrosine-protein kinase SYK
Detection Range	0.312-20ng/mL
Entryname	KSYK_RAT
Method Type	Sandwich
Platform	PF07714
Protein Name	Tyrosine-protein kinase SYK
Sensitivity	0.156ng/mL
Sequence	50: MAGNAVDNAN ; HLTYFFGNIT ; REEAEDYLVQ ; GGMTDGLYLL ; RQSRNYLGGF ; 100: ALSVAHNRKA ; HHYTIERELN ; GTYAISGGRA ; HASPADLCHY ; HSQEPEGLVC ; 150: LLKKPFNRPP ; GVQPKTGPFE ; DLKENLIREY ; VKQTWNLQGQ ; ALEQAIISQK ; 200: PQLEKLIATT ; AHEKMPWFHG ; NISRDESEQT ; VLIGSKTNGK ; FLIRARDNNG ; 250: SFALCLLHEG ; KVLHYRIDRD ; KTGKLSIPEG ; KKFDTLWQLV ; EHYSYKPDGL ; 300: LRVLTVPCQK ; IGVQMGHPGS ; SNAHPVTWSP ; GGIISRIKSY ; SFPKPGHKKP ; 350: PPPQGSRPES ; TVSFNPYEPT ; GGAWGPDRGL ; QREALPMDTE ; VYESPYADPE ; 400: EIRPKEVYLD ; RKLLTLEDNE ; LGSGNFGTVK ; KGYYQMKKVV ; KTVAVKILKN ; 450: EANDPALKDE ; LLAEANVMQQ ; LDNPYIVRMI ; GICEAESWML ; VMEMAAWGPL ; 500: NKYLQQNRHI ; KDKNIIELVH ; QVSMGMKYLE ; ESNFVHRDLA ; ARNVLLVTQH ; 550: YAKISDFGLS ; KALRADENYY ; KAQTHGKWPV ; KWYAPECINY ; FKFSSKSDVW ; 600: SFGVLMWEAF ; SYGQKPYRGM ; KGSEVTAMLE ; KGERMGCPPG ; CPREMYDLMF ; 629: LCWTYDVENR ; PGFAAVELRL ; RNYYYDVVN
Sequence Length	629
String	Q64725
Sub Unit	Interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL, leading to its destruction. Interacts with phosphorylated NFAM1. Interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation. Interacts with ITGB2 and FGR. Interacts with FCRL3 and RHOH. Interacts (via the second SH2 domain) with USP25 (via C-terminus) (By similarity). Interacts with GAB2. Interacts with YWHAG/1433-gamma, which attenuates BCR-induced membrane translocation and activation.

Uniprot	Q64725
Gene Name	Syk
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25155
Unigene	Rn.87407

Reference	1. "Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing." Rowley R.B., Bolen J.B., Fargnoli J. J. Biol. Chem.270:12659-12664(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING (ISOFORMS SYKA AND SYKB) 2. "SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases." Ruzzene M., Brunati A.M., Marin O., Donella-Deana A., Pinna L.A. Biochemistry35:5327-5332(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HCLS1 3. "Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase." Hong J.J., Yankee T.M., Harrison M.L., Geahlen R.L. J. Biol. Chem.277:31703-31714(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-317 BY LYN;PHOSPHORYLATION AT TYR-342 AND TYR-346

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806338	E1520r	96T	$796		Add to Cart

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