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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 1A

SKU : BHE13811571

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0131r
Alternative Names	Tumor necrosis factor receptor 1 ; TNF-R1 ; Tumor necrosis factor receptor type I ; TNF-RI ; p55 ; p60 ; CD120a ; Tnfr-1 ; Tnfr1
Categories	Elisa
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Specificity	Natural and recombinant Rat Tumor necrosis factor receptor superfamily member 1A
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	78-5000pg/mL
Entryname	TNR1A_RAT
Method Type	Sandwich
Platform	PF00531
Protein Name	Tumor necrosis factor receptor superfamily member 1A
Sensitivity	39pg/mL
Sequence	50: MGLPIVPGLL ; LSLVLLALLM ; GIHPSGVTGL ; VPSLGDREKR ; DNLCPQGKYA ; 100: HPKNNSICCT ; KCHKGTYLVS ; DCPSPGQETV ; CEVCDKGTFT ; ASQNHVRQCL ; 150: SCKTCRKEMF ; QVEISPCKAD ; MDTVCGCKKN ; QFQRYLSETH ; FQCVDCSPCF ; 200: NGTVTIPCKE ; KQNTVCNCHA ; GFFLSGNECT ; PCSHCKKNQE ; CMKLCLPPVA ; 250: NVTNPQDSGT ; AVLLPLVIFL ; GLCLLFFICI ; SLLCRYPQWR ; PRVYSIICRD ; 300: SAPVKEVEGE ; GIVTKPLTPA ; SIPAFSPNPG ; FNPTLGFSTT ; PRFSHPVSST ; 350: PISPVFGPSN ; WHNFVPPVRE ; VVPTQGADPL ; LYGSLNPVPI ; PAPVRKWEDV ; 400: VAAQPQRLDT ; ADPAMLYAVV ; DGVPPTRWKE ; FMRLLGLSEH ; EIERLELQNG ; 450: RCLREAHYSM ; LEAWRRRTPR ; HEATLDVVGR ; VLCDMNLRGC ; LENIRETLES ; 461: PAHSSTTHLP ; R
Sequence Length	461
String	P22934
Sub Unit	Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP.

Uniprot	P22934
Gene Name	Tnfrsf1a
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25625
Unigene	Rn.11119

Reference	1. "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein." Himmler A., Maurer-Fogy I., Kroenke M., Scheurich P., Pfizenmaier K., Lantz M., Olsson I., Hauptmann R., Stratowa C., Adolf G.R. DNA Cell Biol.9:705-715(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains." Furuya T., Salstrom J.L., Joe B., Hashiramoto A., Dobbins D.E., Wilder R.L., Remmers E.F. Immunogenetics53:427-429(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-230 AND PRO-295 strain: ACI/SegHsd. strain: BB(DR)/Wor. strain: Brown Norway/SsNHsd. strain: DA/Bkl. strain: F344/NHsd. strain: LEW/NHsd. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-230 AND PRO-295 tissue: Kidney.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811571	E0131r	96T	$796		Add to Cart

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