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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Tryptase beta-2

SKU : BHE13811330

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0258r
Alternative Names	Mast cell protease 6 ; rMCP-6 ; Mcp6 ; Mcpt6
Categories	Elisa
Function	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection.
Specificity	Natural and recombinant Rat Tryptase beta-2
Subcellular Location	Secreted Released from the secretory granules upon mast cell activation.
Detection Range	0.156-10ng/mL
Entryname	TRYB2_RAT
Method Type	Sandwich
Platform	PF00089
Protein Name	Tryptase beta-2
Sensitivity	0.082ng/mL
Sequence	50: MLKLLLLLAL ; SPLASLVHAA ; PCPVKQRVGI ; VGGREASESK ; WPWQVSLRFK ; 100: FSFWMHFCGG ; SLIHPQWVLT ; AAHCVGLHIK ; SPELFRVQLR ; EQYLYYADQL ; 150: LTVNRTVVHP ; HYYTVEDGAD ; IALLELEIPV ; NVSTHIHPIS ; LPPASETFPS ; 200: GTSCWVTGWG ; DIDSDEPLLP ; PYPLKQVKVP ; IVENSLCDRK ; YHTGLYTGDD ; 250: VPIVQDGMLC ; AGNTRSDSCQ ; GDSGGPLVCK ; VKGTWLQAGV ; VSWGEGCAEA ; 274: NRPGIYTRVT ; YYLDWIHRYV ; PQRS
Sequence Length	274
Sub Unit	Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

Uniprot	P50343
Gene Name	Tpsb2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29268
Unigene	Rn.10183

Reference	1. "cDNA sequencing and expression of rat mast cell tryptase." Ide H., Itoh H., Tomita M., Murakumo Y., Kobayashi T., Maruyama H., Osada Y., Nawa Y. J. Biochem.118:210-215(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Peritoneal mast cell. 2. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations." Lutzelschwab C., Pejler G., Aveskogh M., Hellman L. J. Exp. Med.185:13-29(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Peritoneal mast cell.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811330	E0258r	96T	$796		Add to Cart

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