ELISA Kit for Rat Tribbles homolog 3

Mfr.No.	E9844r
Alternative Names	Neuronal cell death-inducible putative kinase ; Nipk
Categories	Elisa
Function	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
Specificity	Natural and recombinant Rat Tribbles homolog 3
Subcellular Location	Nucleus
Detection Range	0.156-10 ng/ml
Entryname	TRIB3_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Tribbles homolog 3
Sensitivity	0.08 ng/mL
Sequence	50: MRATSLAASA ; DVPCRKKPLE ; FDDNIDVECP ; VLKRVRDEPE ; PGPTPSLPPA ; 100: SDLSPAVAPA ; TRLGPYILLE ; REQGNCTYRA ; LHCPTGTEYT ; CKVYPASEAQ ; 150: AVLAPYARLP ; THQHVARPTE ; VLLGSQLLYT ; FFTKTHGDLH ; SLVRSRRGIP ; 200: EPEAAALFRQ ; MASAVAHCHK ; HGLILRDLKL ; RRFVFSNCER ; TKLVLENLED ; 250: ACVMTGPDDS ; LWDKHACPAY ; VGPEILSSRP ; SYSGRAADVW ; SLGVALFTML ; 300: AGRYPFQDSE ; PALLFGKIRR ; GTFALPEGLS ; ASARCLIRCL ; LRREPSERLV ; 349: ALGILLHPWL ; REDCSQVSPP ; RSDRREMDQV ; VPDGPQLEEA ; EEGEVGLYG
Sequence Length	349
String	Q9WTQ6
Sub Unit	Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.

Reference	1. "Identification of a novel kinase-like gene induced during neuronal cell death." Mayumi-Matsuda K., Kojima S., Suzuki H., Sakata T. Biochem. Biophys. Res. Commun.258:260-264(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Neuron. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Liver. 3. "Lack of evidence for a role of TRB3/NIPK as inhibitor of PKB-mediated insulin signaling in primary hepatocytes." Iynedjian P.B. Biochem. J.386:113-118(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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BHE13811852	E9844r	96T	$796		Add to Cart