5DIII ; DIOIII ; Type 3 DI ; Type III iodothyronine deiodinase ; Itdi3 ; Txdi3
Categories
Elisa
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Specificity
Natural and recombinant Rat Thyroxine 5-deiodinase
Subcellular Location
Cell membrane Single-pass type II membrane protein Endosome membrane Single-pass type II membrane protein