ELISA Kit for Rat Suppressor of cytokine signaling 2

Mfr.No.	E1415r
Alternative Names	Cytokine-inducible SH2 protein 2 ; Cish2
Categories	Elisa
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Specificity	Natural and recombinant Rat Suppressor of cytokine signaling 2
Detection Range	0.156-10ng/mL
Entryname	SOCS2_RAT
Method Type	Sandwich
Platform	PF00017
Protein Name	Suppressor of cytokine signaling 2
Sensitivity	0.078ng/mL
Sequence	50: MTLRCLEPSG ; NGADRTRSQW ; GTAGSPEDQS ; PEAARLAKAL ; RELSQTGWYW ; 100: GSMTVNEAKE ; KLKEAPEGTF ; LIRDSSHSDY ; LLTISVKTSA ; GPTNLRIEYQ ; 150: DGKFRLDSII ; CVKSKLKQFD ; SVVHLIDYYV ; QMCKDKRTGP ; EAPRNGTVHL ; 198: YLTKPLYTSA ; PTLQHFCRLS ; INKCTGTIRG ; LPLPTRLKDY ; LEEYKFQV
Sequence Length	198
String	O88582
Sub Unit	Associates with the Elongin BC complex.

Reference	1. "Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo." Mao Y., Ling P.R., Fitzgibbons T.P., McCowen K.C., Frick G.P., Bistrian B.R., Smith R.J. Endocrinology140:5505-5515(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Liver.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13810848	E1415r	96T	$796		Add to Cart