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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Sterol regulatory element-binding protein 2

SKU : BHE13810280

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12196r
Alternative Names	Sterol regulatory element-binding transcription factor 2
Categories	Elisa
Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Specificity	Natural and recombinant Rat Sterol regulatory element-binding protein 2
Subcellular Location	Processed sterol regulatory element-binding protein 2 Nucleus
Detection Range	0.156-10ng/mL
Entryname	SRBP2_RAT
Method Type	Sandwich
Platform	PF00010
Protein Name	Sterol regulatory element-binding protein 2
Sensitivity	0.078ng/mL
Sequence	50: MDENSELGGL ; ETMETLTELG ; DELTLGDIDE ; MLQFVSNQVG ; EFSDLFSEQL ; 100: CSSFPGGGGG ; SGSGGTSNNS ; SGRGTSGGAA ; DPAVQRSFSQ ; VPLSTFSPSS ; 150: TSPQAPALQV ; KVSPTPPRAT ; PVLQPRPQPQ ; PQPPAQLQQQ ; TVMITPTFST ; 200: APQTRIIQQP ; LIYQNAATSF ; QVLQPQVQSL ; VTSSQVQPVT ; IQQQVQTVQA ; 250: QRVLTQTANG ; TLQTLAPATV ; QTVATPQVQQ ; VPVLVQPQII ; KTDSLVLTTL ; 300: KTDGSPVMAA ; VQNPALTALT ; APIQTAALQV ; PTLVGSNGAI ; LTTMPVMMGQ ; 350: EKVPIKQVPG ; GVKQLEPPKE ; GERRTTHNII ; EKRYRSSIND ; KIIELKDLVM ; 400: GTDAKMHKSG ; VLRKAIDYIK ; YLQQVNHKLR ; QENMVLKLAN ; QKNKLLKGID ; 450: LGSLVDSDVD ; LKIDDFNQNV ; LLMSPPASDS ; GSQAGFSPYS ; IDSEPGSPLL ; 500: DDAKVKDEPD ; SPPVALGMVD ; RSRILLCVLT ; FLGLSFNPLT ; SLLQWGGAHN ; 550: PDQHPYSGSG ; RNVLSLESGS ; GGWFDWMMPT ; LLLWLLNGVI ; VLSVFVKLLV ; 600: HGEPVIRPHS ; RSSVTFWRHR ; KQADLDLAKG ; DFAAAAANLQ ; TCLSVLGRAL ; 650: PTSRLDLACS ; LSWNVIRYSL ; QKLRLVRWLL ; KKVFQRWRAT ; PATAAGFEDE ; 700: AKSSARDAAL ; AYHRLHQLHI ; TGKLPAGSAC ; SDVHMALCAV ; NLAECAEEKI ; 750: PPSTLVEIHL ; TAAMGLKTRC ; GGKLGFLASY ; FLNRAQSLCG ; PEHSAVPDSL ; 800: RWLCHPLGQK ; FFMERSWSIK ; SAAKDSLYCA ; QRNPADPIAQ ; VHQAFCKHLL ; 850: ERAVEALVKP ; QAKKKAGDRE ; EESCEFSSAL ; EFLKLLHSFV ; DSVGFVASPF ; 900: SSSSVLRSAL ; GPDVVCRWWT ; SAITVAISWL ; QGDDAAVRSH ; FTEVERVPKA ; 950: LEVTESPLVK ; AVFYACRAMH ; ASLSGKADGQ ; QNSFCHCERA ; SGHLWSSLNV ; 1000: SGTTSDPSLN ; HVVQLLTCDL ; LLSLRTTLWQ ; KQASASQLLG ; ETYHASGTEL ; 1050: AGFQRDLGSL ; RRLAHSFRPA ; YRKVFLHEAT ; VRLMAGASPT ; RTHQLLEHSL ; 1100: RRRTTQNTKH ; GEVDTWPGQR ; ERATAILLAC ; RHLPLSFLSS ; PGQRAVLLAE ; 1133: AARTLEKVGD ; RRSCSDCQQM ; IVKLGGGTAI ; AAS
Sequence Length	1133
String	Q3T1I5
Sub Unit	Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminus domain) with RNF139.

Uniprot	Q3T1I5
Gene Name	Srebf2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:300095
Unigene	Rn.41063

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Prostate.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810280	E12196r	96T	$796		Add to Cart

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