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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Sodium/potassium-transporting ATPase subunit alpha-1

SKU : BHE13800214

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12570r
Alternative Names	Sodium pump subunit alpha-1
Categories	Elisa
Function	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Specificity	Natural and recombinant Rat Sodium/potassium-transporting ATPase subunit alpha-1
Subcellular Location	Cell membrane Multi-pass membrane protein Melanosome
Detection Range	15.6-1000pg/mL
Entryname	AT1A1_RAT
Method Type	Sandwich
Platform	PF00689
Protein Name	Sodium/potassium-transporting ATPase subunit alpha-1
Sensitivity	7.82pg/mL
Sequence	50: MGKGVGRDKY ; EPAAVSEHGD ; KKSKKAKKER ; DMDELKKEVS ; MDDHKLSLDE ; 100: LHRKYGTDLS ; RGLTPARAAE ; ILARDGPNAL ; TPPPTTPEWV ; KFCRQLFGGF ; 150: SMLLWIGAIL ; CFLAYGIRSA ; TEEEPPNDDL ; YLGVVLSAVV ; IITGCFSYYQ ; 200: EAKSSKIMES ; FKNMVPQQAL ; VIRNGEKMSI ; NAEDVVVGDL ; VEVKGGDRIP ; 250: ADLRIISANG ; CKVDNSSLTG ; ESEPQTRSPD ; FTNENPLETR ; NIAFFSTNCV ; 300: EGTARGIVVY ; TGDRTVMGRI ; ATLASGLEGG ; QTPIAEEIEH ; FIHLITGVAV ; 350: FLGVSFFILS ; LILEYTWLEA ; VIFLIGIIVA ; NVPEGLLATV ; TVCLTLTAKR ; 400: MARKNCLVKN ; LEAVETLGST ; STICSDKTGT ; LTQNRMTVAH ; MWFDNQIHEA ; 450: DTTENQSGVS ; FDKTSATWFA ; LSRIAGLCNR ; AVFQANQENL ; PILKRAVAGD ; 500: ASESALLKCI ; EVCCGSVMEM ; REKYTKIVEI ; PFNSTNKYQL ; SIHKNPNASE ; 550: PKHLLVMKGA ; PERILDRCSS ; ILLHGKEQPL ; DEELKDAFQN ; AYLELGGLGE ; 600: RVLGFCHLLL ; PDEQFPEGFQ ; FDTDEVNFPV ; DNLCFVGLIS ; MIDPPRAAVP ; 650: DAVGKCRSAG ; IKVIMVTGDH ; PITAKAIAKG ; VGIISEGNET ; VEDIAARLNI ; 700: PVNQVNPRDA ; KACVVHGSDL ; KDMTSEELDD ; ILRYHTEIVF ; ARTSPQQKLI ; 750: IVEGCQRQGA ; IVAVTGDGVN ; DSPALKKADI ; GVAMGIVGSD ; VSKQAADMIL ; 800: LDDNFASIVT ; GVEEGRLIFD ; NLKKSIAYTL ; TSNIPEITPF ; LIFIIANIPL ; 850: PLGTVTILCI ; DLGTDMVPAI ; SLAYEQAESD ; IMKRQPRNPK ; TDKLVNERLI ; 900: SMAYGQIGMI ; QALGGFFTYF ; VILAENGFLP ; FHLLGIRETW ; DDRWINDVED ; 950: SYGQQWTYEQ ; RKIVEFTCHT ; AFFVSIVVVQ ; WADLVICKTR ; RNSVFQQGMK ; 1000: NKILIFGLFE ; ETALAAFLSY ; CPGMGAALRM ; YPLKPTWWFC ; AFPYSLLIFV ; 1023: YDEVRKLIIR ; RRPGGWVEKE ; TYY
Sequence Length	1023
String	P06685
Sub Unit	Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with SIK1.

Uniprot	P06685
Gene Name	Atp1a1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24211
Unigene	Rn.217534

Reference	1. "Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain." Shull G.E., Greeb J., Lingrel J.B. Biochemistry25:8125-8132(1986) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. tissue: Kidney. 2. "Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences." Hara Y., Urayama O., Kawakami K., Nojima H., Nagamune H., Kojima T., Ohta T., Nagano K., Nakao M. J. Biochem.102:43-58(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 3. "Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications." Herrera V.L.M., Emanuel J.R., Ruiz-Opazo N., Levenson R., Nadal-Ginard B. J. Cell Biol.105:1855-1865(1987) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Prostate. 5. Lubec G., Kang S.U. Submitted (2007-07) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 157-162; 597-605; 630-647; 662-671 AND 744-773;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Brain. 6. "Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA." Schneider J.W., Mercer R.W., Caplan M., Emanuel J.R., Sweadner K.J., Benz E.J. Jr., Levenson R. Proc. Natl. Acad. Sci. U.S.A.82:6357-6361(1985) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 489-533 tissue: Brain. 7. "Cloning and analysis of the 5'-flanking region of rat Na+/K(+)-ATPase alpha 1 subunit gene." Yagawa Y., Kawakami K., Nagano K. Biochim. Biophys. Acta1049:286-292(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41 8. "Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis." Fisone G., Cheng S.X.-J., Nairn A.C., Czernik A.J., Hemmings H.C. Jr., Hoeoeg J.-O., Bertorello A.M., Kaiser R., Bergman T., Joernvall H., Aperia A., Greengard P. J. Biol. Chem.269:9368-9373(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMP-DEPENDENT KINASE 9. "Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA." Cheng X.J., Hoeoeg J.O., Nairn A.C., Greengard P., Aperia A. Am. J. Physiol.273:C1981-C1986(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-23 AND SER-943 10. "Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10." Feraille E., Carranza M.L., Gonin S., Beguin P., Pedemonte C., Rousselot M., Caverzasio J., Geering K., Martin P.Y., Favre H. Mol. Biol. Cell10:2847-2859(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-10 11. "Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C." Feschenko M.S., Sweadner K.J. J. Biol. Chem.270:14072-14077(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;PHOSPHORYLATION AT SER-16 AND SER-23 BY PROTEIN KINASE C 12. "Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking." Yudowski G.A., Efendiev R., Pedemonte C.H., Katz A.I., Berggren P.-O., Bertorello A.M. Proc. Natl. Acad. Sci. U.S.A.97:6556-6561(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING SITE FOR PHOSPHOINOSITIDE-3 KINASE;MUTAGENESIS 13. "SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process." Sjostrom M., Stenstrom K., Eneling K., Zwiller J., Katz A.I., Takemori H., Bertorello A.M. Proc. Natl. Acad. Sci. U.S.A.104:16922-16927(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION;INTERACTION WITH SIK1 14. "ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase." Hilge M., Siegal G., Vuister G.W., Guntert P., Gloor S.M., Abrahams J.P. Nat. Struct. Biol.10:468-474(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 383-595 ALONE AND IN COMPLEX WITH ATP;ATP-BINDING SITE

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