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ELISA Kit for Rat Sodium channel protein type 8 subunit alpha

SKU : BHE13810210

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15346r
Alternative Names	Peripheral nerve protein type 4 ; PN4 ; Sodium channel 6 ; NaCh6 ; Sodium channel protein type VIII subunit alpha ; Voltage-gated sodium channel subunit alpha Nav1.6
Categories	Elisa
Function	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Specificity	Natural and recombinant Rat Sodium channel protein type 8 subunit alpha
Subcellular Location	Membrane Multi-pass membrane protein
Entryname	SCN8A_RAT
Platform	PF11933
Protein Name	Sodium channel protein type 8 subunit alpha
Sequence	50: MAARLLAPPG ; PDSFKPFTPE ; SLANIERRIA ; ESKLKKPPKA ; DGSHREDDED ; 100: SKPKPNSDLE ; AGKSLPFIYG ; DIPQGLVAVP ; LEDFDPYYLT ; QKTFVVLNRG ; 150: KTLFRFSATP ; ALYILSPFNL ; IRRIAIKILI ; HSVFSMIIMC ; TILTNCVFMT ; 200: FSNPPEWSKN ; VEYTFTGIYT ; FESLVKIIAR ; GFCIDGFTFL ; RDPWNWLDFS ; 250: VIMMAYVTEF ; VDLGNVSALR ; TFRVLRALKT ; ISVIPGLKTI ; VGALIQSVKK ; 300: LSDVMILTVF ; CLSVFALIGL ; QLFMGNLRNK ; CVVWPINFNE ; SYLENGTRGF ; 350: DWEEYINNKT ; NFYMVPGMLE ; PLLCGNSSDA ; GQCPEGFQCM ; KAGRNPNYGY ; 400: TSFDTFSWAF ; LALFRLMTQD ; YWENLYQLTL ; RAAGKTYMIF ; FVLVIFVGSF ; 450: YLVNLILAVV ; AMAYEEQNQA ; TLEEAEQKEA ; EFKAMLEQLK ; KQQEEAQAAA ; 500: MATSAGTVSE ; DAIEEEGEDG ; VGSPRSSSEL ; SKLSSKSAKE ; RRNRRKKRKQ ; 550: KELSEGEEKG ; DPEKVFKSES ; EDGMRRKAFR ; LPDNRIGRKF ; SIMNQSLLSI ; 600: PGSPFLSRHN ; SKSSIFSFRG ; PGRFRDPGSE ; NEFADDEHST ; VEESEGRRDS ; 650: LFIPIRARER ; RSSYSGYSGY ; SQCSRSSRIF ; PSLRRSVKRN ; STVDCNGVVS ; 700: LIGPGSHIGR ; LLPEATTEVE ; IKKKGPGSLL ; VSMDQLASYG ; RKDRINSIMS ; 750: VVTNTLVEEL ; EESQRKCPPC ; WYKFANTFLI ; WECHPYWIKL ; KEIVNLIVMD ; 800: PFVDLAITIC ; IVLNTLFMAM ; EHHPMTPQFE ; HVLAVGNLVF ; TGIFTAEMFL ; 850: KLIAMDPYYY ; FQEGWNIFDG ; FIVSLSLMEL ; SLADVEGLSV ; LRSFRLLRVF ; 900: KLAKSWPTLN ; MLIKIIGNSV ; GALGNLTLVL ; AIIVFIFAVV ; GMQLFGKSYK ; 950: ECVCKINQEC ; KLPRWHMNDF ; FHSFLIVFRV ; LCGEWIETMW ; DCMEVAGQAM ; 1000: CLIVFMMVMV ; IGNLVVLNLF ; LALLLSSFSA ; DNLAATDDDG ; EMNNLQISVI ; 1050: RIKKGVAWTK ; VKVHAFMQAH ; FKQREADEVK ; PLDELYEKKA ; NCIANHTGVD ; 1100: IHRNGDFQKN ; GNGTTSGIGS ; SVEKYIIDED ; HMSFINNPNL ; TVRVPIAVGE ; 1150: SDFENLNTED ; VSSESDPEGS ; KDKLDDTSSS ; EGSTIDIKPE ; VEEVPVEQPE ; 1200: EYLDPDACFT ; EGCVQRFKCC ; QVNIEEGLGK ; SWWILRKTCF ; LIVEHNWFET ; 1250: FIIFMILLSS ; GALAFEDIYI ; EQRKTIRTIL ; EYADKVFTYI ; FILEMLLKWT ; 1300: AYGFVKFFTN ; AWCWLDFLIV ; AVSLVSLIAN ; ALGYSELGAI ; KSLRTLRALR ; 1350: PLRALSRFEG ; MRVVVNALVG ; AIPSIMNVLL ; VCLIFWLIFS ; IMGVNLFAGK ; 1400: YHYCFNETSE ; IRFEIDIVNN ; KTDCEKLMEG ; NSTEIRWKNV ; KINFDNVGAG ; 1450: YLALLQVATF ; KGWMDIMYAA ; VDSRKPDEQP ; DYEGNIYMYI ; YFVIFIIFGS ; 1500: FFTLNLFIGV ; IIDNFNQQKK ; KFGGQDIFMT ; EEQKKYYNAM ; KKLGSKKPQK ; 1550: PIPRPLNKIQ ; GIVFDFVTQQ ; AFDIVIMMLI ; CLNMVTMMVE ; TDTQSKQMEN ; 1600: ILYWINLVFV ; IFFTCECVLK ; MFALRHYYFT ; IGWNIFDFVV ; VILSIVGMFL ; 1650: ADIIEKYFVS ; PTLFRVIRLA ; RIGRILRLIK ; GAKGIRTLLF ; ALMMSLPALF ; 1700: NIGLLLFLVM ; FIFSIFGMSN ; FAYVKHEAGI ; DDMFNFETFG ; NSMICLFQIT ; 1750: TSAGWDGLLL ; PILNRPPDCS ; LDKEHPGSGF ; KGDCGNPSVG ; IFFFVSYIII ; 1800: SFLIVVNMYI ; AIILENFSVA ; TEESADPLSE ; DDFETFYEIW ; EKFDPDATQF ; 1850: IEYCKLADFA ; DALEHPLRVP ; KPNTIELIAM ; DLPMVSGDRI ; HCLDILFAFT ; 1900: KRVLGDSGEL ; DILRQQMEER ; FVASNPSKVS ; YEPITTTLRR ; KQEEVSAVVL ; 1950: QRAYRGHLAR ; RGFICRKMAS ; NKLENGGTHR ; DKKESTPSTA ; SLPSYDSVTK ; 1978: PDKEKQQRAE ; EGRRERAKRQ ; KEVRESKC
Sequence Length	1978
String	O88420
Sub Unit	Interacts with NEDD4 and NEDD4L.

Uniprot	O88420
Gene Name	Scn8a
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29710
Unigene	Rn.91216

Reference	1. "Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia." Dietrich P.S., McGivern J.G., Delgado S.G., Koch B.D., Eglen R.M., Hunter J.C., Sangameswaran L. J. Neurochem.70:2262-2272(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY tissue: Spinal ganglion. 2. "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons." Wittmack E.K., Rush A.M., Craner M.J., Goldfarb M., Waxman S.G., Dib-Hajj S.D. J. Neurosci.24:6765-6775(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF13

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