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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Signal transducer and activator of transcription 3

SKU : BHE13811102

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1743r
Categories	Elisa
Function	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
Specificity	Natural and recombinant Rat Signal transducer and activator of transcription 3
Subcellular Location	Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3.
Detection Range	0.156-10ng/mL
Entryname	STAT3_RAT
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 3
Sensitivity	0.082ng/mL
Sequence	50: MAQWNQLQQL ; DTRYLEQLHQ ; LYSDSFPMEL ; RQFLAPWIES ; QDWAYAASKE ; 100: SHATLVFHNL ; LGEIDQQYSR ; FLQESNVLYQ ; HNLRRIKQFL ; QSRYLEKPME ; 150: IARIVARCLW ; EESRLLQTAA ; TAAQQGGQAN ; HPTAAVVTEK ; QQMLEQHLQD ; 200: VRKRVQDLEQ ; KMKVVENLQD ; DFDFNYKTLK ; SQGDMQDLNG ; NNQSVTRQKM ; 250: QQLEQMLTAL ; DQMRRSIVSE ; LAGLLSAMEY ; VQKTLTDEEL ; ADWKRRQQIA ; 300: CIGGPPNICL ; DRLENWITSL ; AESQLQTRQQ ; IKKLEELQQK ; VSYKGDPIVQ ; 350: HRPMLEERIV ; DLFRNLMKSA ; FVVERQPCMP ; MHPDRPLVIK ; TGVQFTTKVR ; 400: LLVKFPELNY ; QLKIKVCIDK ; DSGDVAALRG ; SRKFNILGTN ; TKVMNMEESN ; 450: NGSLSAEFKH ; LTLREQRCGN ; GGRANCDASL ; IVTEELHLIT ; FETEVYHQGL ; 500: KIDLETHSLP ; VVVISNICQM ; PNAWASILWY ; NMLTNNPKNV ; NFFTKPPIGT ; 550: WDQVAEVLSW ; QFSSTTKRGL ; SIEQLTTLAE ; KLLGPGVNYS ; GCQITWAKFC ; 600: KENMAGKGFS ; FWVWLDNIID ; LVKKYILALW ; NEGYIMGFIS ; KERERAILST ; 650: KPPGTFLLRF ; SESSKEGGVT ; FTWVEKDISG ; KTQIQSVEPY ; TKQQLNNMSF ; 700: AEIIMGYKIM ; DATNILVSPL ; VYLYPDIPKE ; EAFGKYCRPE ; SQEHPEADPG ; 750: SAAPYLKTKF ; ICVTPTTCSN ; TIDLPMSPRT ; LDSLMQFGNN ; GEGAEPSAGG ; 770: QFESLTFDMD ; LTSECATSPM ;
Sequence Length	770
String	P52631
Sub Unit	Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation. Interacts with NEK6. Binds to CDK9 when activated and nuclear (By similarity). Interacts with BMX.

Uniprot	P52631
Gene Name	Stat3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25125
Unigene	Rn.10247

Reference	1. "Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements." Ripperger J.A., Fritz S., Richter K., Hocke G.M., Lottspeich F., Fey G.H. J. Biol. Chem.270:29998-30006(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Kidney. 3. "Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin." Kwon H., Jeong K., Hwang E.M., Park J.-Y., Hong S.-G., Choi W.-S., Pak Y. Biochim. Biophys. Acta1793:1325-1333(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAV2

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811102	E1743r	96T	$796		Add to Cart

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