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ELISA Kit for Rat Serine/threonine-protein kinase TAO2

SKU : BHE13810147

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2239r
Alternative Names	Thousand and one amino acid protein 2 ; Tao2
Categories	Elisa
Function	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation.
Specificity	Natural and recombinant Rat Serine/threonine-protein kinase TAO2
Subcellular Location	Isoform 2 Cell projection dendrite In dendrites, colocalizes with PCDH8.
Detection Range	0.156-10ng/mL
Entryname	TAOK2_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase TAO2
Sensitivity	0.086ng/mL
Sequence	50: MPAGGRAGSL ; KDPDVAELFF ; KDDPEKLFSD ; LREIGHGSFG ; AVYFARDVRN ; 100: SEVVAIKKMS ; YSGKQSNEKW ; QDIIKEVRFL ; QKLRHPNTIQ ; YRGCYLREHT ; 150: AWLVMEYCLG ; SASDLLEVHK ; KPLQEVEIAA ; VTHGALQGLA ; YLHSHNMIHR ; 200: DVKAGNILLS ; EPGLVKLGDF ; GSASIMAPAN ; SFVGTPYWMA ; PEVILAMDEG ; 250: QYDGKVDVWS ; LGITCIELAE ; RKPPLFNMNA ; MSALYHIAQN ; ESPALQSGHW ; 300: SEYFRNFVDS ; CLQKIPQDRP ; TSEVLLKHRF ; VLRERPPTVI ; MDLIQRTKDA ; 350: VRELDNLQYR ; KMKKILFQEA ; PNGPGAEAPE ; EEEEAEPYMH ; RAGTLTSLES ; 400: SHSVPSMSIS ; ASSQSSSVNS ; LADASDNEEE ; EEEEEEEEEE ; EEEEGPESRE ; 450: MAMMQEGEHT ; VTSHSSIIHR ; LPGSDNLYDD ; PYQPEMTPGP ; LQPPAAPPTS ; 500: TSSSSARRRA ; YCRNRDHFAT ; IRTASLVSRQ ; IQEHEQDSAL ; REQLSGYKRM ; 550: RRQHQKQLLA ; LESRLRGERE ; EHSGRLQREL ; EAQRAGFGTE ; AEKLARRHQA ; 600: IGEKEARAAQ ; AEERKFQQHI ; LGQQKKELAA ; LLEAQKRTYK ; LRKEQLKEEL ; 650: QENPSTPKRE ; KAEWLLRQKE ; QLQQCQAEEE ; AGLLRRQRQY ; FELQCRQYKR ; 700: KMLLARHSLD ; QDLLREDLNK ; KQTQKDLECA ; LLLRQHEATR ; ELELRQLQAV ; 750: QRTRAELTRL ; QHQTELGNQL ; EYNKRREQEL ; RQKHAAQVRQ ; QPKSLKVRAG ; 800: QLPMGLPATG ; ALGPLSTGTL ; SEEQPCSSGQ ; EAILGQRMLG ; EEEEAVPERM ; 850: ILGKEGTTLE ; PEEQRILGEE ; MGTFSSSPQK ; HRSLVNEEDW ; DISKEMKESR ; 900: VPSLASQERN ; IIGQEEAGAW ; NLWEKEHGNL ; VDMEFKLGWV ; QGPVLTPVPE ; 950: EEEEEEEEGG ; APIGTPRDPG ; DGCPSPDIPP ; EPPPSHLRQY ; PASQLPGFLS ; 1000: HGLLTGLSFA ; VGSSSGLLPL ; LLLLLLPLLA ; AQGGGGLQAA ; LLALEVGLVG ; 1050: LGASYLFLCT ; ALHLPPSLFL ; LLAQGTALGA ; VLSLSWRRGL ; MGVPLGLGAA ; 1100: WLLAWPSLAL ; PLAAMAAGGK ; WVRQQGPQMR ; RGISRLWLRV ; LLRLSPMVFR ; 1150: ALQGCAAVGD ; RGLFALYPKT ; NKNGFRSRLP ; VPWPRQGNPR ; TTQHPLALLA ; 1200: RVWALCKGWN ; WRLARASHRL ; ASCLPPWAVH ; ILASWGLLKG ; ERPSRIPRLL ; 1235: PRSQRRLGLS ; ASRQLPPGTV ; AGRRSQTRRA ; LPPWR
Sequence Length	1235
String	Q9JLS3
Sub Unit	Self-associates. Interacts with MAP2K3 and MAP2K6. Interacts with tubulins. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation (By similarity). Isoform 2 interacts with PCDH8; this complex may also include CDH2.

Uniprot	Q9JLS3
Gene Name	Taok2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:64666
Unigene	Rn.9575

Reference	1. "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain." Chen Z., Hutchison M., Cobb M.H. J. Biol. Chem.274:28803-28807(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH MAP2K3 AND MAP2K6 tissue: Brain. 2. "Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases." Yasuda S., Tanaka H., Sugiura H., Okamura K., Sakaguchi T., Tran U., Takemiya T., Mizoguchi A., Yagita Y., Sakurai T., De Robertis E.M., Yamagata K. Neuron56:456-471(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH PCDH8;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-57;PHOSPHORYLATION AT SER-1038 (ISOFORM 2) 3. "Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K." Zhou T., Raman M., Gao Y., Earnest S., Chen Z., Machius M., Cobb M.H., Goldsmith E.J. Structure12:1891-1900(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-320;PHOSPHORYLATION AT SER-181 4. "Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine." Zhou T.J., Sun L.G., Gao Y., Goldsmith E.J. Acta Biochim. Biophys. Sin.38:385-392(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-320 IN COMPLEX WITH STAUROSPORINE;ENZYME REGULATION

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