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ELISA Kit for Rat Serine/threonine-protein kinase PLK1

SKU : BHE13809482

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1662r
Antigen	Plk1
Alternative Names	Polo-like kinase 1 ; PLK-1 ; Plk
Categories	Elisa
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
Specificity	Natural and recombinant Rat Serine/threonine-protein kinase PLK1
Subcellular Location	Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.
Detection Range	15.6-1000pg/mL
Entryname	PLK1_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase PLK1
Sensitivity	7.84pg/mL
Sequence	50: MNAAAKAGKL ; ARAPADLGKG ; GVPGDAVPGA ; PVAAPLAKEI ; PEVLVDPRSR ; 100: QQYVRGRFLG ; KGGFAKCFEI ; SDSDTKEVFP ; GKIVPKSLLL ; KPHQKEKMSM ; 150: ETSIHRSLEH ; QHVVGFHGFF ; EDSDFVFVVL ; ELCRRRSLLE ; LHKRRKALTE ; 200: PEARYYLRQI ; VLGCQYLHRN ; QVIHRDLKLG ; NLFLNEDLEV ; KIGDFGLATK ; 250: VEYEGERKKT ; LCGTPNYIAP ; EVLSKKGHSF ; EVDVWSIGCI ; MYTLLVGKPP ; 300: FETSCLKETY ; LRIKKNEYSI ; PKHINPVAAS ; LIQKMLQTDP ; AARPTIHELL ; 350: NDEFFTSGYI ; PARLPITCLT ; IPPRFSIAPS ; SLDPSNRKPL ; TVLNKGVENP ; 400: LPDRPREKEE ; PVVRETNEAI ; ECHLSDLLQQ ; LTSVNASKPS ; ERGLVRQEEA ; 450: EDPACIPIFW ; VSKWVDYSDK ; YGLGYQLCDN ; SVGVLFNDST ; RLILYNDGDS ; 500: LQYIERDGTE ; SYLTVSSHPN ; SLMKKITLLN ; YFRNYMSEHL ; LKAGANITPR ; 550: EGDELARLPY ; LRTWFRTRSA ; IILHLSNGTV ; QINFFQDHTK ; LIRGPLMAAV ; 600: TYINEKRDFR ; TYRLSLLEEY ; GCCKELASRL ; RYARTMVDKL ; LSSRSACNRL ; 603: KAS
Sequence Length	603
String	Q62673
Sub Unit	Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, MLF1IP and CDC25C. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD.

Uniprot	Q62673
Gene Name	Plk1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25515
Unigene	Rn.11034

Reference	1. Amstrup J., Hansen J.A., Hxirlis Nielsen J. Submitted (1994-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Pancreas. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Testis.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809482	E1662r	96T	$796		Add to Cart

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