ELISA Kit for Rat Serine/threonine-protein kinase pim-1

Mfr.No.	E1997r
Alternative Names	Pim-1
Categories	Elisa
Function	May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B (By similarity). Also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3 (By similarity). Plays a role in signal transduction in blood cells (By similarity). Contributes to both cell proliferation and survival thus providing a selective advantage in tumorigenesis.
Specificity	Natural and recombinant Rat Serine/threonine-protein kinase pim-1
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.156-10ng/mL
Entryname	PIM1_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase pim-1
Sensitivity	0.083ng/mL
Sequence	50: MLLSKINSLA ; HLRAAPCNDL ; HANKLAPGKE ; KEPLESQYQV ; GPLLGSGGFG ; 100: SVYSGIRVAD ; NLPVAIKHVE ; KDRISDWGEL ; PNGTRVPMEV ; VLLKKVSSGF ; 150: SGVIRLLDWF ; ERPDSFVLIL ; ERPEPVQDLF ; DFITERGALQ ; EELARSFFWQ ; 200: VLEAVRHCHN ; CGVLHRDIKD ; ENILIDLNRG ; ELKLIDFGSG ; ALLKDTVYTD ; 250: FDGTRVYSPP ; EWIRYHRYHG ; RSAAVWSLGI ; LLYDMVCGDI ; PFEHDEEIVK ; 300: GQVYFRQRVS ; SECQHLIRWC ; LSLRPSDRPS ; FEEIQNHPWM ; QDVLLPQATA ; 313: EIHLHSLSPS ; PSK
Sequence Length	313
String	P26794
Sub Unit	Binds to RP9 (By similarity). Interacts with CDKN1B and FOXO3.

Reference	1. "Characterization of the testes-specific pim-1 transcript in rat." Wingett D., Reeves R., Magnuson N.S. Nucleic Acids Res.20:3183-3189(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Testis. 2. "Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway." Mochizuki T., Kitanaka C., Noguchi K., Muramatsu T., Asai A., Kuchino Y. J. Biol. Chem.274:18659-18666(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25A;INTERACTION WITH CDC25A

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809204	E1997r	96T	$796		Add to Cart