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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Serine/threonine-protein kinase PAK 1

SKU : BHE13808665

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13344r
Alternative Names	Alpha-PAK ; Protein kinase MUK2 ; p21-activated kinase 1 ; PAK-1 ; p68-PAK
Categories	Elisa
Function	The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Specificity	Natural and recombinant Rat Serine/threonine-protein kinase PAK 1
Detection Range	0.156-10ng/mL
Entryname	PAK1_RAT
Method Type	Sandwich
Platform	PF00786
Protein Name	Serine/threonine-protein kinase PAK 1
Sensitivity	0.088ng/mL
Sequence	50: MSNNGLDVQD ; KPPAPPMRNT ; STMIGAGSKD ; PGTLNHGSKP ; LPPNPEEKKK ; 100: KDRFYRSILA ; GDKTNKKKEK ; ERPEISLPSD ; FEHTIHVGFD ; AVTGEFTGMP ; 150: EQWARLLQTS ; NITKSEQKKN ; PQAVLDVLEF ; YNSKKTSNSQ ; KYMSFTDKSA ; 200: EDYNSSNTLN ; VKTVSETPAV ; PPVSEDEDDD ; DDATPPPVIA ; PRPEHTKSVY ; 250: TRSVIEPLPV ; TPTRDVATSP ; ISPTENNTTP ; PDALTRNTEK ; QKKKPKMSDE ; 300: EILEKLRSIV ; SVGDPKKKYT ; RFEKIGQGAS ; GTVYTAMDVA ; TGQEVAIKQM ; 350: NLQQQPKKEL ; IINEILVMRE ; NKNPNIVNYL ; DSYLVGDELW ; VVMEYLAGGS ; 400: LTDVVTETCM ; DEGQIAAVCR ; ECLQALEFLH ; SNQVIHRDIK ; SDNILLGMDG ; 450: SVKLTDFGFC ; AQITPEQSKR ; STMVGTPYWM ; APEVVTRKAY ; GPKVDIWSLG ; 500: IMAIEMIEGE ; PPYLNENPLR ; ALYLIATNGT ; PELQNPEKLS ; AIFRDFLNRC ; 544: LEMDVEKRGS ; AKELLQHQFL ; KIAKPLSSLT ; PLIAAAKEAT ; KNNH
Sequence Length	544
String	P35465
Sub Unit	Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK. Interacts with SCRIB. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM (via cytoplasmic domain); the interaction is direct and enhanced in presence of RAC1.

Uniprot	P35465
Gene Name	Pak1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29431
Unigene	Rn.9149

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808665	E13344r	96T	$796		Add to Cart

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