The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex.
Specificity
Natural and recombinant Rat Serine-threonine kinase receptor-associated protein
Subcellular Location
Cytoplasm Nucleus Localized predominantly in the cytoplasm but also found in the nucleus.
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP.
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