ELISA Kit for Rat Serine/arginine-rich splicing factor 2

Mfr.No.	E11550r
Alternative Names	Splicing component ; 35 kDa ; Splicing factor SC35 ; SC-35 ; Splicing factor ; arginine/serine-rich 2 ; Sfrs2
Categories	Elisa
Function	Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA.
Specificity	Natural and recombinant Rat Serine/arginine-rich splicing factor 2
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	SRSF2_RAT
Method Type	Sandwich
Platform	PF00076
Protein Name	Serine/arginine-rich splicing factor 2
Sensitivity	0.048ng/mL
Sequence	50: MSYGRPPPDV ; EGMTSLKVDN ; LTYRTSPDTL ; RRVFEKYGRV ; GDVYIPRDRY ; 100: TKESRGFAFV ; RFHDKRDAED ; AMDAMDGAVL ; DGRELRVQMA ; RYGRPPDSHH ; 150: SRRGPPPRRY ; GGGGYGRRSR ; SPRRRRRSRS ; RSRSRSRSRS ; RSRYSRSKSR ; 200: SRTRSRSRST ; SKSRSARRSK ; SKSSSVSRSR ; SRSRSRSRSR ; SPPPVSKRES ; 221: KSRSRSKSPP ; KSPEEEGAVS ; S
Sequence Length	221
String	Q6PDU1
Sub Unit	In vitro, salf-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus) (By similarity). Interacts with CCNL1.

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Pituitary. 2. "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin." Berke J.D., Sgambato V., Zhu P.-P., Lavoie B., Vincent M., Krause M., Hyman S.E. Neuron32:277-287(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCNL1

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