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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Runt-related transcription factor 1

SKU : BHE13810199

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10487r
Alternative Names	Acute myeloid leukemia 1 protein ; Core-binding factor subunit alpha-2 ; CBF-alpha-2 ; Oncogene AML-1 ; Polyomavirus enhancer-binding protein 2 alpha B subunit ; PEA2-alpha B ; Aml1 ; Cbfa2
Categories	Elisa
Function	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Inhibits KAT6B-dependent transcriptional activation.
Specificity	Natural and recombinant Rat Runt-related transcription factor 1
Subcellular Location	Nucleus
Entryname	RUNX1_RAT
Platform	PF00853
Protein Name	Runt-related transcription factor 1
Sequence	50: MRIPVDASTS ; RRFTPPSTAL ; SPGKMSEALP ; LGAPDGGAAL ; ASKLRSGDRS ; 100: MVEVLADHPG ; ELVRTDSPNF ; LCSVLPTHWR ; CNKTLPIAFK ; VVALGDVPDG ; 150: TLVTVMAGND ; ENYSAELRNA ; TAAMKNQVAR ; FNDLRFVGRS ; GRGKSFTLTI ; 200: TVFTNPPQVA ; TYHRAIKITV ; DGPREPRRHR ; QKLDDQTKPG ; SLSFSERLSE ; 250: LEQLRRTAMR ; VSPHHPAPTP ; NPRASLNHST ; AFNPQPQSQM ; QDARQIQPSP ; 300: PWSYDQSYQY ; LGSITSSVHP ; ATPISPGRAS ; GMTSLSAELS ; SRLSTAPDLT ; 350: AFGDPRQFPT ; LPSISDPRMH ; YPGAFTYSPP ; VTSGIGIGMS ; AMSSTSRYHT ; 400: YLPPPYPGSS ; QAQAGPFQTG ; SPSYHLYYGT ; SAGSYQFSMV ; GGERSPPRIL ; 450:
Sequence Length	450
String	Q63046
Sub Unit	Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1 (By similarity). Interacts with YAP1 and HIPK2. Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity.

Uniprot	Q63046
Gene Name	Runx1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:50662
Unigene	Rn.11201

Reference	1. "AML1 is expressed in skeletal muscle and is regulated by innervation." Zhu X., Yeadon J.E., Burden S.J. Mol. Cell. Biol.14:8051-8057(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION strain: Sprague-Dawley. tissue: Skeletal muscle.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810199	E10487r	96T	$796		Add to Cart

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