Liver regeneration-related protein LRRG199 ; Rho-associated ; coiled-coil-containing protein kinase 1 ; Rho-associated ; coiled-coil-containing protein kinase I ; ROCK-I ; p150 RhoA-binding kinase ROK beta ; p160 ROCK-1 ; p160ROCK ; Ac2-154
Categories
Elisa
Function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.
Specificity
Natural and recombinant Rat Rho-associated protein kinase 1
Subcellular Location
Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes.
Homodimer (By similarity). Interacts with GEM, MYLC2B, RHOE, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC and PPP1R12A.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH RHOA; RHOB AND RHOC;TISSUE SPECIFICITY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ROLE IN SMOOTH MUSCLE CONTRACTION AND HYPERTENSION;INHIBITION BY Y-27632
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1R12A;SUBCELLULAR LOCATION
Reviews of ELISA Kit for Rat Rho-associated protein kinase 1