JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Reticulon-4

SKU : BHE13810095

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E12266r
Alternative Names	Foocen ; Glut4 vesicle 20 kDa protein ; Neurite outgrowth inhibitor ; Nogo protein ; Nogo
Categories	Elisa
Function	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Specificity	Natural and recombinant Rat Reticulon-4
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Detection Range	78-5000pg/mL
Entryname	RTN4_RAT
Method Type	Sandwich
Platform	PF02453
Protein Name	Reticulon-4
Sensitivity	40.6pg/mL
Sequence	50: MEDIDQSSLV ; SSSTDSPPRP ; PPAFKYQFVT ; EPEDEEDEEE ; EEDEEEDDED ; 100: LEELEVLERK ; PAAGLSAAAV ; PPAAAAPLLD ; FSSDSVPPAP ; RGPLPAAPPA ; 150: APERQPSWER ; SPAAPAPSLP ; PAAAVLPSKL ; PEDDEPPARP ; PPPPPAGASP ; 200: LAEPAAPPST ; PAAPKRRGSG ; SVDETLFALP ; AASEPVIPSS ; AEKIMDLMEQ ; 250: PGNTVSSGQE ; DFPSVLLETA ; ASLPSLSPLS ; TVSFKEHGYL ; GNLSAVSSSE ; 300: GTIEETLNEA ; SKELPERATN ; PFVNRDLAEF ; SELEYSEMGS ; SFKGSPKGES ; 350: AILVENTKEE ; VIVRSKDKED ; LVCSAALHSP ; QESPVGKEDR ; VVSPEKTMDI ; 400: FNEMQMSVVA ; PVREEYADFK ; PFEQAWEVKD ; TYEGSRDVLA ; ARANVESKVD ; 450: RKCLEDSLEQ ; KSLGKDSEGR ; NEDASFPSTP ; EPVKDSSRAY ; ITCASFTSAT ; 500: ESTTANTFPL ; LEDHTSENKT ; DEKKIEERKA ; QIITEKTSPK ; TSNPFLVAVQ ; 550: DSEADYVTTD ; TLSKVTEAAV ; SNMPEGLTPD ; LVQEACESEL ; NEATGTKIAY ; 600: ETKVDLVQTS ; EAIQESLYPT ; AQLCPSFEEA ; EATPSPVLPD ; IVMEAPLNSL ; 650: LPSAGASVVQ ; PSVSPLEAPP ; PVSYDSIKLE ; PENPPPYEEA ; MNVALKALGT ; 700: KEGIKEPESF ; NAAVQETEAP ; YISIACDLIK ; ETKLSTEPSP ; DFSNYSEIAK ; 750: FEKSVPEHAE ; LVEDSSPESE ; PVDLFSDDSI ; PEVPQTQEEA ; VMLMKESLTE ; 800: VSETVAQHKE ; ERLSASPQEL ; GKPYLESFQP ; NLHSTKDAAS ; NDIPTLTKKE ; 850: KISLQMEEFN ; TAIYSNDDLL ; SSKEDKIKES ; ETFSDSSPIE ; IIDEFPTFVS ; 900: AKDDSPKLAK ; EYTDLEVSDK ; SEIANIQSGA ; DSLPCLELPC ; DLSFKNIYPK ; 950: DEVHVSDEFS ; ENRSSVSKAS ; ISPSNVSALE ; PQTEMGSIVK ; SKSLTKEAEK ; 1000: KLPSDTEKED ; RSLSAVLSAE ; LSKTSVVDLL ; YWRDIKKTGV ; VFGASLFLLL ; 1050: SLTVFSIVSV ; TAYIALALLS ; VTISFRIYKG ; VIQAIQKSDE ; GHPFRAYLES ; 1100: EVAISEELVQ ; KYSNSALGHV ; NSTIKELRRL ; FLVDDLVDSL ; KFAVLMWVFT ; 1150: YVGALFNGLT ; LLILALISLF ; SIPVIYERHQ ; VQIDHYLGLA ; NKSVKDAMAK ; 1163: IQAKIPGLKR ; KAD
Sequence Length	1163
String	Q9JK11
Sub Unit	Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact ith BACE1 and BACE2 (By similarity). Interacts with RTN4IP1 (By similarity). Interacts in trans with CNTNAP1. Interacts with ATL1.

Uniprot	Q9JK11
Gene Name	Rtn4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	o:83765
Unigene	Rn.1348

Reference	1. "Cloning and characterization of a 22 kDa protein from rat adipocytes: a new member of the reticulon family." Morris N.J., Ross S.A., Neveu J.M., Lane W.S., Lienhard G.E. Biochim. Biophys. Acta1450:68-76(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);PARTIAL PROTEIN SEQUENCE strain: Sprague-Dawley. tissue: Adipocyte. 2. "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1." Chen M.S., Huber A.B., Van der Haar M.E., Frank M., Schnell L., Spillmann A.A., Christ F., Schwab M.E. Nature403:434-439(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3) 3. "Cloning of a member of the reticulon gene family in rat: one of two minor splice variants." Ito T., Schwartz S.M. Submitted (1999-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4) strain: Wistar Kyoto. tissue: Vascular smooth muscle. 4. "Nogo-66 receptor antagonist peptide promotes axonal regeneration." GrandPre T., Li S., Strittmatter S.M. Nature417:547-551(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 5. "Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization." Nie D.-Y., Zhou Z.-H., Ang B.-T., Teng F.Y.H., Xu G., Xiang T., Wang C.-Y., Zeng L., Takeda Y., Xu T.-L., Ng Y.K., Faivre-Sarrailh C., Popko B., Ling E.-A., Schachner M., Watanabe K., Pallen C.J., Tang B.L., Xiao Z.-C.more... EMBO J.22:5666-5678(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNTNAP1 6. "Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions." Oertle T., van der Haar M.E., Bandtlow C.E., Robeva A., Burfeind P., Buss A., Huber A.B., Simonen M., Schnell L., Brosamle C., Kaupmann K., Vallon R., Schwab M.E. J. Neurosci.23:5393-5406(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 7. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 8. "A class of dynamin-like GTPases involved in the generation of the tubular ER network." Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C. Cell138:549-561(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATL1 9. "Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system." Petrinovic M.M., Duncan C.S., Bourikas D., Weinman O., Montani L., Schroeter A., Maerki D., Sommer L., Stoeckli E.T., Schwab M.E. Development137:2539-2550(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13810095	E12266r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.