ELISA Kit for Rat Ras-related GTP-binding protein A

Mfr.No.	E3277r
Categories	Elisa
Function	Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
Specificity	Natural and recombinant Rat Ras-related GTP-binding protein A
Subcellular Location	Cytoplasm Nucleus Lysosome Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state.
Entryname	RRAGA_RAT
Platform	PF04670
Protein Name	Ras-related GTP-binding protein A
Sequence	50: MPNTAMKKKV ; LLMGKSGSGK ; TSMRSIIFAN ; YIARDTRRLG ; ATIDVEHSHV ; 100: RFLGNLVLNL ; WDCGGQDTFM ; ENYFTSQRDN ; IFRNVEVLIY ; VFDVESRELE ; 150: KDMHYYQSCL ; EAILQNSPDA ; KIFCLVHKMD ; LVQEDQRDLI ; FKEREEDLRR ; 200: LSRPLECACF ; RTSIWDETLY ; KAWSSIVYQL ; IPNVQQLEMN ; LRNFAQIIEA ; 250: DEVLLFERAT ; FLVISHYQCK ; EQRDVHRFEK ; ISNIIKQFKL ; SCSKLAASFQ ; 300: SMEVRNSNFA ; AFIDIFTSNT ; YVMVVMSDPS ; IPSAATLINI ; RNARKHFEKL ; 313: ERVDGPKHSL ; LMR
Sequence Length	313
String	Q63486
Sub Unit	Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8.

Reference	1. "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases." Schuermann A., Brauers A., Massmann S., Becker W., Joost H.-G. J. Biol. Chem.270:28982-28988(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;GTP-BINDING strain: Sprague-Dawley. tissue: Brain. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Prostate.

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BHE13809930	E3277r	96T	$796		Add to Cart