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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Protein S100-A9

SKU : BHE13809730

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1793r
Alternative Names	Calgranulin-B ; Migration inhibitory factor-related protein 14 ; MRP-14 ; Myeloid-related protein 14 ; S100 calcium-binding protein A9 ; Mrp14
Categories	Elisa
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions (By similarity). Stimulates proliferation of fibroblast cells as both a monomer and a homodimer. May act as a mitogen during chronic inflammation.
Specificity	Natural and recombinant Rat Protein S100-A9
Subcellular Location	Secreted Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes.
Detection Range	0.156-10ng/mL
Entryname	S10A9_RAT
Method Type	Sandwich
Platform	PF01023
Protein Name	Protein S100-A9
Sensitivity	0.084ng/mL
Sequence	50: MAAKTGSQLE ; RSISTIINVF ; HQYSRKYGHP ; DTLNKAEFKE ; MVNKDLPNFL ; 100: KREKRNENLL ; RDIMEDLDTN ; QDNQLSFEEC ; MMLMGKLIFA ; CHEKLHENNP ; 113: RGHDHSHGKG ; CGK
Sequence Length	113
String	P50116
Sub Unit	Homodimer. Heterotetramer with S100A8. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells. The homodimer interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. The homodimer binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions (By similarity). Monomer and/or homodimer; disulfide-linked.

Uniprot	P50116
Gene Name	S100a9
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:94195
Unigene	Rn.6703

Reference	1. "Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats." Imamichi T., Uchida I., Wahl S.M., McCartney-Francis N. Biochem. Biophys. Res. Commun.194:819-825(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: Lewis/N. tissue: Peritoneal cavity. 2. "Identification of posttranslational modifications and cDNA sequencing errors in the rat S100 proteins MRP8 and 14 using electrospray ionization mass spectrometry." Raftery M.J., Geczy C.L. Anal. Biochem.258:285-292(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-57; 62-65 AND 72-113;MASS SPECTROMETRY;ACETYLATION AT ALA-2;METHYLATION AT HIS-107 tissue: Spleen. 3. "Fibroblast growth-stimulating activity of S100A9 (MRP-14)." Shibata F., Miyama K., Shinoda F., Mizumoto J., Takano K., Nakagawa H. Eur. J. Biochem.271:2137-2143(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-113;PROTEIN SEQUENCE OF 11-25; 38-67; 81-90 AND 94-112;FUNCTION;SUBUNIT;TISSUE SPECIFICITY strain: Wistar. tissue: Macrophage. tissue: Peritoneal cavity. 4. "Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction." Koike A., Arai S., Yamada S., Nagae A., Saita N., Itoh H., Uemoto S., Totani M., Ikemoto M. Inflammation35:409-419(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809730	E1793r	96T	$796		Add to Cart

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