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ELISA Kit for Rat Prestin

SKU : BHE13810075

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15288r
Alternative Names	Solute carrier family 26 member 5 ; Pres
Categories	Elisa
Function	Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.
Specificity	Natural and recombinant Rat Prestin
Subcellular Location	Cell membrane Multi-pass membrane protein Lateral wall of outer hair cells.
Entryname	S26A5_RAT
Platform	PF01740
Protein Name	Prestin
Sequence	50: MDHAEENEIP ; AETQKYLVER ; PIFSHPVLQE ; RLHVKDKVTD ; SIGDKLKQAF ; 100: TCTPKKVRNI ; IYMFLPITKW ; LPAYKFKEYV ; LGDLVSGIST ; GVLQLPQGLA ; 150: FAMLAAVPPV ; FGLYSSFYPV ; IMYCFFGTSR ; HISIGPFAVI ; SLMIGGVAVR ; 200: LVPDDIVIPG ; GVNATNGTEA ; RDALRVKVAM ; SVTLLSGIIQ ; FCLGVCRFGF ; 250: VAIYLTEPLV ; RGFTTAAAVH ; VFTSMLKYLF ; GVKTKRYSGI ; FSVVYSTVAV ; 300: LQNVKNLNVC ; SLGVGLMVFG ; LLLGGKEFNE ; RFKEKLPAPI ; PLEFFAVVMG ; 350: TGISAGFNLH ; ESYSVDVVGT ; LPLGLLPPAN ; PDTSLFHLVY ; VDAIAIAIVG ; 400: FSVTISMAKT ; LANKHGYQVD ; GNQELIALGI ; CNSIGSLFQT ; FSISCSLSRS ; 450: LVQEGTGGKT ; QLAGCLASLM ; ILLVILATGF ; LFESLPQAVL ; SAIVIVNLKG ; 500: MFMQFSDLPF ; FWRTSKIELT ; IWLTTFVSSL ; FLGLDYGLIT ; AVIIALLTVI ; 550: YRTQSPSYTV ; LGQLPDTDVY ; IDIDAYEEVK ; EIPGIKIFQI ; NAPIYYANSD ; 600: LYSSALKRKT ; GVNPAIIMGA ; RRKAMRKYAK ; EVGNANIANA ; TVVKVDAEVD ; 650: GENATKPEEE ; DDEVKFPPIV ; IKTTFPEELQ ; RFLPQGENIH ; TVILDFTQVN ; 700: FMDSVGVKTL ; AGIVKEYGDV ; GIYVYLAGCS ; AQVVNDLTSN ; RFFENPALKE ; 744: LLFHSIHDAV ; LGSQVREAMA ; EQETTVLPPQ ; EDMEPNATPT ; TPEA
Sequence Length	744
String	Q9EPH0

Uniprot	Q9EPH0
Gene Name	Slc26a5
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:83819
Unigene	Rn.64631

Reference	1. "Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells." Ludwig J., Oliver D., Frank G., Kloecker N., Gummer A.W., Fakler B. Proc. Natl. Acad. Sci. U.S.A.98:4178-4183(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TOPOLOGY tissue: Cochlea. 2. "Dynamic developmental expression of cochlear hair cell genes: prestin and otoferlin." Beisel K.W., Nelson N.C., Beisel C.L., Delimont D.C., He D.Z.Z., Fritzsch B. Submitted (2000-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 249-668 strain: Sprague-Dawley. 3. "Thyroid horomone is a critical determinant for the regulation of the cochlear motor protein prestin." Weber T., Zimmermann U., Winter H., Mack A., Koepschall I., Rohbock K., Zenner H.P., Knipper M. Submitted (2002-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-20 strain: Sprague-Dawley. 4. "Expression and localization of prestin and the sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells." Belyantseva I.A., Adler H.J., Curi R., Frolenkov G.I., Kachar B. J. Neurosci.20:RC116-RC116(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 5. "Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein." Oliver D., He D.Z.Z., Kloecker N., Ludwig J., Schulte U., Waldegger S., Ruppersberg J.P., Dallos P., Fakler B. Science292:2340-2343(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MODE OF ACTION;MUTAGENESIS OF ASP-154; ASP-155; GLU-169; LYS-177; ARG-197; LYS-233; LYS-235; ARG-236; GLU-277; ARG-281; LYS-283; LYS-285; ASP-332; ASP-342; LYS-409; LYS-557; ARG-558; LYS-559; ARG-571; ARG-572 AND LYS-577

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BHE13810075	E15288r	96T	$796		Add to Cart

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