Heterogeneous nuclear ribonucleoprotein I ; hnRNP I ; Pyrimidine-binding protein ; PYBP ; Ptb ; Pybp ; Tbfii
Categories
Elisa
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.
Specificity
Natural and recombinant Rat Polypyrimidine tract-binding protein 1
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 185-205; 348-365 AND 517-549
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-13; 84-91; 122-133; 435-452 AND 496-506;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY