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ELISA Kit for Rat Platelet endothelial cell adhesion molecule

SKU : BHE13809059

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0363r
Alternative Names	CD31 ; Pecam
Categories	Elisa
Function	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis.
Specificity	Natural and recombinant Rat Platelet endothelial cell adhesion molecule
Subcellular Location	Membrane Single-pass type I membrane protein Cell junction Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Detection Range	0.156-10ng/mL
Entryname	PECA1_RAT
Method Type	Sandwich
Protein Name	Platelet endothelial cell adhesion molecule
Sensitivity	0.086ng/mL
Sequence	50: MLLALLLTML ; LYASLQAQEN ; SFTINSIHME ; SRPSWEVSNG ; QKLTLQCLVD ; 100: ISTTSKSRPQ ; HQVLFYKDDA ; LVYNVSSSEH ; TESFVIPQSR ; VFHAGKYKCT ; 150: VILNSKEKTT ; IEYQLTVNGV ; PMPEVTVDKK ; EVTEGGIVTV ; NCSMQEEKPP ; 200: IYFKIEKVEL ; GTKNVKLSRE ; KTSNMNFVLI ; EFPIEEQDHL ; LVFRCQAGVL ; 250: SGIKMQTSEF ; IRSEYVTVQE ; FFSTPKFQIQ ; PPEMIIEGNQ ; LHIKCSVQVA ; 300: HLAQEFPEII ; IQKDKAIVAT ; SKQSKEAVYS ; VMALVEHSGH ; YTCKVESNRI ; 350: SKASSILVNI ; TELFPRPKLE ; LSSSRLDQGE ; MLDLSCSVSG ; APVANFTIQK ; 400: EETVLSQYQN ; FSKIAEERDS ; GLYSCTAGIG ; KVVKRSNLVP ; VQVCEMLSKP ; 450: RIFHDAKFEI ; IKGQIIGISC ; QSVNGTAPIT ; YRLLRAKSNF ; QTVQKNSNDP ; 500: VTFTDKPTRD ; MEYQCIVDNC ; HSHPEVRSEI ; LRVKVIAPVD ; EVTISILSGN ; 550: DVQSGDEMVL ; RCSVKEGTGP ; VTFQFYKEKE ; GRPFHEETVN ; DTQVFWHHEQ ; 600: TSKEQEGQYY ; CTAFNRASIV ; TSLRSGPLTV ; RVFLAPWKKG ; LIAVVVIGVV ; 650: IAALIVAAKY ; YFLRKAKAKQ ; KPVEMSRPAV ; PLLNSNSEKV ; SEPSVETNSH ; 678: YDSQNMDVEY ; TEVEVSSLEP ; HQENGRLP
Sequence Length	678
Sub Unit	Interacts with PTPN11. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

Uniprot	Q3SWT0
Gene Name	Pecam1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29583
Unigene	Rn.1878

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Spleen. 2. "Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution." Pepper M.S., Baetens D., Mandriota S.J., Di Sanza C., Oikemus S., Lane T.F., Soriano J.V., Montesano R., Iruela-Arispe M.L. Dev. Dyn.218:507-524(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 283-624 strain: Sprague-Dawley.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809059	E0363r	96T	$796		Add to Cart

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