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ELISA Kit for Rat Phosphatidylcholine-sterol acyltransferase

SKU : BHE13806597

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2114r
Alternative Names	Lecithin-cholesterol acyltransferase ; Phospholipid-cholesterol acyltransferase
Categories	Elisa
Function	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines.
Specificity	Natural and recombinant Rat Phosphatidylcholine-sterol acyltransferase
Subcellular Location	Secreted Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
Detection Range	0.156-10ng/mL
Entryname	LCAT_RAT
Method Type	Sandwich
Platform	PF02450
Protein Name	Phosphatidylcholine-sterol acyltransferase
Sensitivity	0.079ng/mL
Sequence	50: MGLPGSPWQW ; VLLLLGLLLP ; PATSFWLLNV ; LFPPHTTPKA ; ELSNHTRPVI ; 100: LVPGCMGNRL ; EAKLDKPNVV ; NWLCYRKTED ; FFTIWLDFNM ; FLPLGVDCWI ; 150: DNTRVVYNRS ; SGHMSNAPGV ; QIRVPGFGKT ; YSVEYLDDNK ; LAGYLNTLVQ ; 200: NLVNNGYVRD ; ETVRAAPYDW ; RLAPRQQDEY ; YQKLAGLVEE ; MYAAYGKPVF ; 250: LIGHSLGCLH ; VLHFLLRQPQ ; SWKDHFIDGF ; ISLGAPWGGS ; IKPMRILASG ; 300: DNQGIPIMSN ; IKLREEQRIT ; TTSPWMFPAH ; HVWPEDHVFI ; STPNFNYTGQ ; 350: DFERFFADLH ; FEEGWHMFLQ ; SRDLLAGLPA ; PGVEVYCLYG ; VGMPTAHTYI ; 400: YDHNFPYKDP ; VAALYEDGDD ; TVATRSTELC ; GQVQGRQSQG ; VHLLRMNGTD ; 440: HLNMVFSNKT ; LEHINAILLG ; AYPHGTPKSP ; TASLGPPPTE ;
Sequence Length	440
String	P18424

Uniprot	P18424
Gene Name	Lcat
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.10481

Reference	1. "Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat." Meroni G., Malgaretti N., Magnaghi P., Taramelli R. Nucleic Acids Res.18:5308-5308(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates." Subbaiah P.V., Liu M. J. Lipid Res.37:113-122(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBSTRATE SPECIFICITY 3. "Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains." Zhao Y., Wang J., Gebre A.K., Chisholm J.W., Parks J.S. Biochemistry42:13941-13949(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBSTRATE SPECIFICITY;MUTAGENESIS OF ALA-173

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806597	E2114r	96T	$796		Add to Cart

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