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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Perforin-1

SKU : BHE13808818

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1317r
Alternative Names	Cytolysin ; Lymphocyte pore-forming protein ; Pfp
Categories	Elisa
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Specificity	Natural and recombinant Rat Perforin-1
Subcellular Location	Cytoplasmic granule lumen Secreted Cell membrane Multi-pass membrane protein Endosome lumen Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.
Detection Range	0.156-10ng/mL
Entryname	PERF_RAT
Method Type	Sandwich
Platform	PF00168
Protein Name	Perforin-1
Sensitivity	0.081ng/mL
Sequence	50: MAAYLFLLGL ; FLLLPRPVPA ; PCYTATRSEC ; KQNHKFVPGV ; WAAGEGVDVT ; 100: TLRRSSSFPV ; NTGKFLRPDR ; TCTLCKNALM ; NDGIQRLPVA ; IAHWRPHGSH ; 150: CQRNVATTKV ; SSTEGVAREA ; AANINNDWRA ; GLDVNPKPEA ; NVHVSVAGSH ; 200: SKIANFAAEK ; AHQDQYNFNT ; DTVECRMYSF ; RLAQKPPLHP ; DFRKALKNLP ; 250: HNFNSSTEHA ; YRRLISSYGT ; HFITAVDLGG ; RVSVLTALRT ; CQLTLDGLTA ; 300: DEVGDCLSVE ; AQVSIGAQAS ; VSSEYKACEE ; KKKQHKIATS ; FHQTYRERHV ; 350: EVLGGPLDSS ; NDLLFGNQAT ; PEHFSTWIAS ; LPTRPDVVDY ; SLEPLHILLE ; 400: DSDPKREALR ; QAISHYVMSR ; ARWRDCNRPC ; RAGQHKSSRD ; SCQCVCQDSN ; 450: VTNQDCCPRQ ; RGLAKLMVRN ; FQAKGLWGDY ; ITSTDAYLKV ; FFGGQEIRTG ; 500: VVWNNNHPSW ; SDKMDFGNVL ; LSTGGPLRVQ ; VWDADNGWDD ; DLLGTCDKSP ; 550: KSGFHEVNCP ; LNHGSIKFIY ; QANCLPDLTG ; ETCLEYAPQG ; LLGDPRGNRS ; 554: GAVW
Sequence Length	554
String	P35763
Sub Unit	Monomer. Homooligomer. Oligomerization is required for pore formation.

Uniprot	P35763
Gene Name	Prf1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.11206

Reference	1. "Molecular cloning of rat cytolysin." Ishikawa H., Shinkai Y., Yagita H., Yue C.C., Henkart P.A., Sawada S., Young H.A., Reynolds C.W., Okumura K. J. Immunol.143:3069-3073(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808818	E1317r	96T	$796		Add to Cart

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