ELISA Kit for Rat Oxysterols receptor LXR-beta

Mfr.No.	E0212r
Alternative Names	Liver X receptor beta ; Nuclear receptor subfamily 1 group H member 2 ; Orphan nuclear receptor OR-1 ; Ubiquitously-expressed nuclear receptor ; UR ; Lxrb
Categories	Elisa
Function	Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Specificity	Natural and recombinant Rat Oxysterols receptor LXR-beta
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	NR1H2_RAT
Method Type	Sandwich
Platform	PF00104
Protein Name	Oxysterols receptor LXR-beta
Sensitivity	0.087ng/mL
Sequence	50: MSSPTSSLDT ; PLPGNGSPQP ; STSSTSPTIK ; EEGQETDPPP ; GSEGSSSAYI ; 100: VVILEPEDEP ; ERKRKKGPAP ; KMLGHELCRV ; CGDKASGFHY ; NVLSCEGCKG ; 150: FFRRSVVHGG ; AGRYACRGSG ; TCQMDAFMRR ; KCQLCRLRKC ; KEAGMREQCV ; 200: LSEEQIRKKK ; IQKQQQQQPP ; PPTEPASGSS ; ARPAASPGTS ; EASSQGSGEG ; 250: EGIQLTAAQE ; LMIQQLVAAQ ; LQCNKRSFSD ; QPKVTPWPLG ; ADPQSRDARQ ; 300: QRFAHFTELA ; IISVQEIVDF ; AKQVPGFLQL ; GREDQIALLK ; ASTIEIMLLE ; 350: TARRYNHETE ; CITFLKDFTY ; SKDDFHRAGL ; QVEFINPIFE ; FSRAMRRLGL ; 400: DDAEYALLIA ; INIFSADRPN ; VQEPSRVEAL ; QQPYVEALLS ; YTRIKRPQDQ ; 446: LRFPRMLMKL ; VSLRTLSSVH ; SEQVFALRLQ ; DKKLPPLLSE ; IWDVHE
Sequence Length	446
String	Q62755
Sub Unit	Forms a heterodimer with RXR.

Reference	1. "OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor." Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M., Gustafsson J.-A. Proc. Natl. Acad. Sci. U.S.A.92:2096-2100(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Liver. 2. "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors." Song C., Kokontis J.M., Hiipakka R.A., Liao S. Proc. Natl. Acad. Sci. U.S.A.91:10809-10813(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Vagina.

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BHE13808574	E0212r	96T	$796		Add to Cart