ELISA Kit for Rat NF-kappa-B inhibitor beta

Mfr.No.	E1849r
Alternative Names	I-kappa-B-beta ; IkB-B ; Ikbb
Categories	Elisa
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Specificity	Natural and recombinant Rat NF-kappa-B inhibitor beta
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.312-20ng/mL
Entryname	IKBB_RAT
Method Type	Sandwich
Platform	PF12796
Protein Name	NF-kappa-B inhibitor beta
Sensitivity	0.189ng/mL
Sequence	50: MAGVACLGKT ; ADADEWCDSG ; LGSLGPDAAA ; PGGPGLVAEL ; SPELSWAPLV ; 100: FGYVTEDGDT ; ALHLAVIHQH ; EPFLDFLLGF ; SAGTEYLDLQ ; NDLGQTALHL ; 150: AAILGEASTV ; EKLYAAGAGV ; LVTERGGHTA ; LHLACRVRAH ; TCAYVLLQPR ; 200: PSHPRDASDT ; YLTQSQDHTP ; DTSHAPVATD ; PQPNPGNEEE ; LRDEDWRLQL ; 250: EAENYDGHTP ; LHVAVIHKDA ; EMVQLLRDAG ; ADLNKPEPTC ; GRTPLHLAVE ; 300: GQAAGVLALL ; LKAGADPTAR ; MYGGRTPLGS ; ALLRPNPVLA ; RLLRAHGAPE ; 350: PEDKDDKLSP ; CSNSSSDSDS ; DNRDEGDEYD ; DIVVHSRRSQ ; NQPPPSPAAK ; 359: PLPDDPNPA
Sequence Length	359
String	Q9JIA3
Sub Unit	Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 (By similarity). Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL.

Reference	1. "Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta." Xu S., Bayat H., Hou X., Jiang B. Am. J. Physiol.291:C1336-C1345(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-19 AND SER-23 2. "Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide synthase type 2 in brain glial cells: the role of I kappa B-beta." Stasiolek M., Gavrilyuk V., Sharp A., Horvath P., Selmaj K., Feinstein D.L. J. Biol. Chem.275:24847-24856(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION

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SKU	Supplier No.	Size	Your price	Quantity
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