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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat NF-kappa-B inhibitor alpha

SKU : BHE13805154

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1848r
Alternative Names	I-kappa-B-alpha ; IkB-alpha ; RL/IF-1 ; Ikba
Categories	Elisa
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Specificity	Natural and recombinant Rat NF-kappa-B inhibitor alpha
Subcellular Location	Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Detection Range	0.156-10ng/mL
Entryname	IKBA_RAT
Method Type	Sandwich
Platform	PF12796
Protein Name	NF-kappa-B inhibitor alpha
Sensitivity	0.078ng/mL
Sequence	50: MFQPAGHGQD ; WAMEGPRDGL ; KKERLVDDRH ; DSGLDSMKDE ; DYEQMVKELR ; 100: EIRLQPQEAP ; LAAEPWKQQL ; TEDGDSFLHL ; AIIHEEKTLT ; MEVIGQVKGD ; 150: LAFLNFQNNL ; QQTPLHLAVI ; TNQPGIAEAL ; LKAGCDPELR ; DFRGNTPLHL ; 200: ACEQGCLASV ; AVLTQTCTPQ ; HLHSVLQATN ; YNGHTCLHLA ; SIHGYLGIVE ; 250: HLVTLGADVN ; AQEPCNGRTA ; LHLAVDLQNP ; DLVSLLLKCG ; ADVNRVTYQG ; 300: YSPYQLTWGR ; PSTRIQQQLG ; QLTLENLQTL ; PESEDEESYD ; TESEFTEDEL ; 314: PYDDCVFGGQ ; RLTL
Sequence Length	314
String	Q63746
Sub Unit	Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA (By similarity). Interacts with PRMT2.

Uniprot	Q63746
Gene Name	Nfkbia
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25493
Unigene	Rn.12550

Reference	1. "Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing Notch-like repeats." Tewari M., Mohn K.L., Yue F.E., Taub R.A. Nucleic Acids Res.20:607-607(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. Tewari M., Mohn K.L., Yue F.E., Taub R.A. Nucleic Acids Res.20:2624-2624(1992) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM 3. Tewari M., Mohn K.L., Yue F.E., Taub R.A. Nucleic Acids Res.20:2931-2931(1992) [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM 4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Pituitary. 6. "Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex." Tewari M., Dobrzanski P., Mohn K.L., Cressman D.E., Hsu J.C., Bravo R., Taub R. Mol. Cell. Biol.12:2898-2908(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805154	E1848r	96T	$796		Add to Cart

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