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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat NF-kappa-B essential modulator

SKU : BHE13808087

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9868r
Alternative Names	IkB kinase-associated protein 1 ; IKKAP1 ; Inhibitor of nuclear factor kappa-B kinase subunit gamma ; I-kappa-B kinase subunit gamma ; NF-kappa-B essential modifier ; Nemo
Categories	Elisa
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3.
Specificity	Natural and recombinant Rat NF-kappa-B essential modulator
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.78-50ng/mL
Entryname	NEMO_RAT
Method Type	Sandwich
Platform	PF11577
Protein Name	NF-kappa-B essential modulator
Sensitivity	0.32ng/mL
Sequence	50: MSRHLWKNQL ; SEMVQPSGGP ; AEDQDMLGEE ; SSLGKPAMLH ; LPSEQGTPET ; 100: LQRCLEENQE ; LRDAIRQSNQ ; MLRERCEELL ; HFQVSQREEK ; EFLMCKFQEA ; 150: RKLVERLSLE ; KLDLRRQREQ ; ALEDLEHLKK ; CQQQMAEDKA ; SVKAQVTSLL ; 200: GELQESQSRL ; EAATKERQTL ; EGRIRAVSEQ ; VRQLESEREV ; LQQQHSVQVD ; 250: QLRMQNQSVE ; AALRMERQAA ; SEEKRKLAQL ; QAAYHQLFQD ; YDSHIKSSKG ; 300: MQLEDLRQQL ; QQAEEALVAK ; QELIDKLKEE ; AEQHKIVMET ; VPVLKAQADI ; 350: YKADFQAERH ; AREKLVERKE ; LLQEQLEQLQ ; REFNKLKVGC ; HESARIEDMR ; 400: KRHVETSQPP ; LLPAPAHHSF ; HLALSNQRRS ; PPEEPPDFCC ; PKCQYQAPDM ; 412: DTLQIHVMEC ; IE
Sequence Length	412
String	Q6TMG5
Sub Unit	Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG (By similarity). Interacts with ZFAND5.

Uniprot	Q6TMG5
Gene Name	Ikbkg
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:309295
Unigene	Rn.214715

Reference	1. "Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines." Saito N., Courtois G., Chiba A., Yamamoto N., Nitta T., Hironaka N., Rowe M., Yamamoto N., Yamaoka S. J. Biol. Chem.278:46565-46575(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Fischer 344.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808087	E9868r	96T	$796		Add to Cart

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