After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Specificity
Natural and recombinant Rat Neuronal acetylcholine receptor subunit alpha-4
Subcellular Location
Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-4-1);NUCLEOTIDE SEQUENCE [MRNA] OF 5-630 (ISOFORM ALPHA-4-2)