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ELISA Kit for Rat Neurogenic locus notch homolog protein 1

SKU : BHE13808128

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0501r
Categories	Elisa
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
Specificity	Natural and recombinant Rat Neurogenic locus notch homolog protein 1
Subcellular Location	Notch 1 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.
Detection Range	78-5000pg/mL
Entryname	NOTC1_RAT
Method Type	Sandwich
Platform	PF00023
Protein Name	Neurogenic locus notch homolog protein 1
Sensitivity	39.4pg/mL
Sequence	50: MPRLLAPLLC ; LTLLPALAAR ; GLRCSQPSGT ; CLNGGRCEVA ; NGTEACVCSG ; 100: AFVGQRCQDP ; SPCLSTPCKN ; AGTCYVVDHG ; GIVDYACSCP ; LGFSGPLCLT ; 150: PLANACLANP ; CRNGGTCDLL ; TLTEYKCRCP ; PGWSGKSCQQ ; ADPCASNPCA ; 200: NGGQCLPFES ; SYICGCPPGF ; HGPTCRQDVN ; ECSQNPGLCR ; HGGTCHNEIG ; 250: SYRCACRATH ; TGPHCELPYV ; PCSPSPCQNG ; GTCRPTGDTT ; HECACLPGFA ; 300: GQNCEENVDD ; CPGNNCKNGG ; ACVDGVNTYN ; CRCPPEWTGQ ; YCTEDVDECQ ; 350: LMPNACQNAG ; TCHNSHGGYN ; CVCVNGWTGE ; DCSDNIDDCA ; SAACFQGATC ; 400: HDRVASFYCE ; CPHGRTGLLC ; HLNDACISNP ; CNEGSNCDTN ; PVNGKAICTC ; 450: PRGYTGPACS ; QDVDECALGA ; NPCEHAGKCL ; NTLGSFECQC ; LQGYTGPRCE ; 500: IDVNECISNP ; CQNDATCLDQ ; IGEFQCICMP ; GYEGVYCEIN ; TDECASSPCL ; 550: HNGRCVDKIN ; EFLCQCPKGF ; SGHLCQYDVD ; ECASTPCKNG ; AKCLDGPNTY ; 600: TCVCTEGYTG ; THCEVDIDEC ; DPDPCHIGLC ; KDGVATFTCL ; CQPGYTGHHC ; 650: ETNINECHSQ ; PCRHGGTCQD ; RDNYYLCLCL ; KGTTGPNCEI ; NLDDCASNPC ; 700: DSGTCLDKID ; GYECACEPGY ; TGSMCNVNID ; ECAGSPCHNG ; GTCEDGIAGF ; 750: TCRCPEGYHD ; PTCLSEVNEC ; NSNPCIHGAC ; RDGLNGYKCD ; CAPGWSGTNC ; 800: DINNNECESN ; PCVNGGTCKD ; MTSGYVCTCR ; EGFSGPNCQT ; NINECASNPC ; 850: LNQGTCIDDV ; AGYKCNCPLP ; YTGATCEVVL ; APCATSPCKN ; SGVCKESEDY ; 900: ESFSCVCPTG ; WQGQTCEIDI ; NECVKSPCRH ; GASCQNTNGS ; YRCLCQAGYT ; 950: GRNCESDIDD ; CRPNPCHNGG ; SCTDGVNAAF ; CDCLPGFQGA ; FCEEDINECA ; 1000: TNPCQNGANC ; TDCVDSYTCT ; CPTGFNGIHC ; ENNTPDCTES ; SCFNGGTCVD ; 1050: GINSFTCLCP ; PGFTGSYCQY ; DVNECDSRPC ; LHGGTCQDSY ; GTYKCTCPQG ; 1100: YTGLNCQNLV ; RWCDSAPCKN ; GGKCWQTNTQ ; YHCECRSGWT ; GFNCDVLSVS ; 1150: CEVAAQKRGI ; DVTLLCQHGG ; LCVDEEDKHY ; CHCQAGYTGS ; YCEDEVDECS ; 1200: PNPCQNGATC ; TDYLGGFSCK ; CVAGYHGSNC ; SEEINECLSQ ; PCQNGGTCID ; 1250: LTNTYKCSCP ; RGTQGVHCEI ; NVDDCHPPLD ; PASRSPKCFN ; NGTCVDQVGG ; 1300: YTCTCPPGFV ; GERCEGDVNE ; CLSNPCDPRG ; TQNCVQRVND ; FHCECRAGHT ; 1350: GRRCESVING ; CRGKPCRNGG ; VCAVASNTAR ; GFICRCPARF ; EGATCENDAR ; 1400: TCGSLRCLNG ; GTCISGPRSP ; TCLCLGSFTG ; PECQFPASSP ; CVGSNPCYNQ ; 1450: GTCEPTSESP ; FYRCLCPAKF ; NGLLCHILDY ; SFTGAAGRDI ; PPPQIEEACE ; 1500: LPECQEDAGN ; KVCNLQCNNH ; ACGWDGGDCS ; LNFNDPWKNC ; TQSLQCWKYF ; 1550: SDGHCDSQCN ; SAGCLFDGFD ; CQLTEGQCNP ; LYDQYCKDHF ; SDGHCDQGCN ; 1600: SAECEWDGLD ; CAEHVPERLA ; AGTLVLVVLL ; PPDQLRNNSF ; HFLRDVSHVL ; 1650: HTNVVFKRDA ; QGQQMIFPYY ; GREEELRKHP ; IKRSAVGWAT ; TSLLPGTNGG ; 1700: RQRRELDPMD ; IHGSIVYLEI ; DNRQCVQSSS ; QCFQSATDVA ; AFLGALASLG ; 1750: SLNIPYKIEA ; VKSETVEPPL ; PSQLHLMYVA ; AAAFVLLFFV ; GCGVLLSRKR ; 1800: RRQHGQLWFP ; EGFKVSEASK ; KKRREPLGED ; SVGLKPLKNA ; SDGALMDDNQ ; 1850: NEWGDEDLET ; KKFRFEEPVV ; LPDLDDQTDH ; RQWTQQHLDA ; ADLRVSAMAP ; 1900: TPPQGEVDAD ; CMDVNVRGPD ; GFTPLMIASC ; SGGGLETGNS ; EEEEDAPAVI ; 1950: SDFIYQGASL ; HNQTDRTGET ; ALHLAARYSR ; SDAAKRLLEA ; SADANIQDNM ; 2000: GRTPLHAAVS ; ADAQGVFQIL ; LRNRATDLDA ; RMHDGTTPLI ; LAARLAVEGM ; 2050: LEDLINSHAD ; VNAVDDLGKS ; ALHWAAAVNN ; VDAAVVLLKN ; GANKDMQNNK ; 2100: EETPLFLAAR ; EGSYETAKVL ; LDHFANRDIT ; DHMDRLPRDI ; AQERMHHDIV ; 2150: RLLDEYNLVR ; SPQLHGTALG ; GTPTLSPTLC ; SPNGYLGNLK ; SATQGKKARK ; 2200: PSTKGLACSS ; KEAKDLKARR ; KKSQDGKGCL ; LDSSSMLSPV ; DSLESPHGYL ; 2250: SDVASPPLLP ; SPFQQSPSMP ; LSHLPGMPDT ; HLGISHLNVA ; AKPEMAALAG ; 2300: GSRLAFEPPP ; PRLSHLPVAS ; SASTVLSTNG ; TGAMNFTVGA ; PASLNGQCEW ; 2350: LPRLQNGMVP ; SQYNPLRPGV ; TPGTLSTQAA ; GLQHGMMGPI ; HSSLSTNTLS ; 2400: PIIYQGLPNT ; RLATQPHLVQ ; TQQVQPQNLQ ; IQPQNLQPPS ; QPHLSVSSAA ; 2450: NGHLGRSFLS ; GEPSQADVQP ; LGPSSLPVHT ; ILPQESQALP ; TSLPSSMVPP ; 2500: MTTTQFLTPP ; SQHSYSSSPV ; DNTPSHQLQV ; PEHPFLTPSP ; ESPDQWSSSS ; 2531: RHSNISDWSE ; GISSPPTSMP ; SQITHIPEAF ; K
Sequence Length	2531
String	Q07008
Sub Unit	Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.

Uniprot	Q07008
Gene Name	Notch1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25496
Unigene	Rn.25046

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