JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Neurabin-2

SKU : BHE13807088

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E8951r
Alternative Names	Neurabin-II ; Neural tissue-specific F-actin-binding protein II ; PP1bp134 ; Protein phosphatase 1 regulatory subunit 9B ; Spinophilin ; p130
Categories	Elisa
Function	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration.
Specificity	Natural and recombinant Rat Neurabin-2
Subcellular Location	Cytoplasm cytoskeleton Nucleus Cell junction synapse Cell junction adherens junction Cell projection dendritic spine Cytoplasm Cell membrane Cell projection lamellipodium Cell projection filopodium Cell projection ruffle membrane Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the post-synaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines. Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Detection Range	0.312-20ng/mL
Entryname	NEB2_RAT
Method Type	Sandwich
Platform	PF00595
Protein Name	Neurabin-2
Sensitivity	0.091ng/mL
Sequence	50: MMKTEPRGPG ; GPLRSASPHR ; SAYEAGIQAL ; KPPDAPGPDE ; APKAAHHKKY ; 100: GSNVHRIKSM ; FLQMGTTTGP ; PGEAGGASGM ; AEAPRASDRG ; VRLSLPRASS ; 150: LNENVDHSAL ; LKLGTSVSER ; VSRFDSKPAP ; SAQPAPPPHP ; PSRLQETRKL ; 200: FERSVPAASG ; GDKEAVARRL ; LRQERASLQD ; RKLDVVVRFN ; GSTEALDKLD ; 250: ADAVSPTVSQ ; LSAVFEKADS ; RTGLHRAPGP ; PRAAGAPQVN ; SKLVTKRSRV ; 300: FQPPPPPPAP ; SGDAATEKDR ; GPGGQQPPQH ; RVAPARPPPK ; PREVRKIKPV ; 350: EVEESGESEA ; ESAPGEVIQA ; EVTVHAALEN ; GSTTATTASP ; APEEPKAEAV ; 400: PEEEASSSVA ; TLERGVDNGR ; APDMAPEEVD ; ESKKEDFSEA ; DLVDVSAYSG ; 450: LGEDSGGSAL ; EEDDEEDEED ; GEPPYEPESG ; CVEIPGLSEE ; EDPAPSRKIH ; 500: FSTAPIQVFS ; TYSNEDYDRR ; NEDVDPMAAS ; AEYELEKRVE ; RLELFPVELE ; 550: KDSEGLGISI ; IGMGAGADMG ; LEKLGIFVKT ; VTEGGAAHRD ; GRIQVNDLLV ; 600: EVDGTSLVGV ; TQSFAASVLR ; NTKGRVRFMI ; GRERPGEQSE ; VAQLIQQTLE ; 650: QERWQREMME ; QRYAQYGEDD ; EETGEYATDE ; DEELSPTFPG ; GEMAIEVFEL ; 700: AENEDALSPV ; EMEPEKLVHK ; FKELQIKHAV ; TEAEIQQLKR ; KLQSLEQEKG ; 750: RWRVEKAQLE ; QSVEENKERM ; EKLEGYWGEA ; QSLCQAVDEH ; LRETQAQYQA ; 800: LERKYSKAKR ; LIKDYQQKEI ; EFLKKETAQR ; RVLEESELAR ; KEEMDKLLDK ; 817: ISELEGNLQT ; LRNSNST
Sequence Length	817
String	O35274
Sub Unit	Possibly exists as an homodimer, homotrimer or an homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with SPATA13 (via C-terminal tail).

Uniprot	O35274
Gene Name	Ppp1r9b
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:84686
Unigene	Rn.6764

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13807088	E8951r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.