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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat NEDD8-activating enzyme E1 catalytic subunit

SKU : BHE13811792

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1027r
Alternative Names	NEDD8-activating enzyme E1C ; Ubiquitin-activating enzyme E1C ; Ubiquitin-like modifier-activating enzyme 3 ; Ubiquitin-activating enzyme 3 ; Ube1c
Categories	Elisa
Function	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Specificity	Natural and recombinant Rat NEDD8-activating enzyme E1 catalytic subunit
Detection Range	0.78-50ng/mL
Entryname	UBA3_RAT
Method Type	Sandwich
Platform	PF08825
Protein Name	NEDD8-activating enzyme E1 catalytic subunit
Sensitivity	0.39ng/mL
Sequence	50: MADGEEPEKK ; RRRIEELLAE ; KMAVDGGCGD ; TGDWEGRWNH ; VKKFLERSGP ; 100: FTHPDFEPST ; ESLQFLLDTC ; KVLVIGAGGL ; GCELLKNLAL ; SGFRQIHVID ; 150: MDTIDVSNLN ; RQFLFRPKDV ; GRPKAEVAAE ; FLNDRVPNCN ; VVPHFNKIQD ; 200: FNDTFYRQFH ; IIVCGLDSII ; ARRWINGMLI ; SLLNYEDGVL ; DPSSIVPLID ; 250: GGTEGFKGNA ; RVILPGMTAC ; IECTLELYPP ; QVNFPMCTIA ; SMPRLPEHCI ; 300: EYVRMLQWPK ; EQPFGDGVPL ; DGDDPEHIQW ; IFQKSVERAS ; QYNIRGVTYR ; 350: LTQGVVKRII ; PAVASTNAVI ; AAVCATEVFK ; IATSAYIPLN ; NYLVFNDVDG ; 400: LYTYTFEAER ; KENCPACSQL ; PQNIQFSPSA ; KLQEVLDYLT ; NSASLQMKSP ; 450: AITATLEGKN ; RTLYLQSVTS ; IEERTRPNLS ; KTLKELGLVD ; GQELAVADVT ; 462: TPQTVLFKLH ; FT
Sequence Length	462
String	Q99MI7
Sub Unit	Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M (By similarity). Binds ESR1 and ESR2 with bound steroid ligand.

Uniprot	Q99MI7
Gene Name	Uba3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	o:117553
Unigene	Rn.162761

Reference	1. "The activating enzyme of NEDD8 inhibits steroid receptor function." Fan M., Long X., Bailey J.A., Reed C.A., Osboe E., Gize E.A., Kirk E.A., Bigsby R.M., Nephew K.P. Mol. Endocrinol.16:315-330(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH ESR1 AND ESR2;TISSUE SPECIFICITY strain: Sprague-Dawley. tissue: Uterus. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Lung.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811792	E1027r	96T	$796		Add to Cart

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